The purpose of this study is to identify the first human gene(s) responsible for Familial Intracranial Aneurysms (FIA).
- DISCOVERY COHORT: Affected and unaffected members, of any age, of families with a known history of intracranial berry aneurysms, who are seen through regular clinics at VGH Neurosurgery or BCCH Medical Genetics. Eligible individuals of any age, gender or ethnicity who have a genetic alteration and a malformation and/or physiological disorder classified as a rare disease will be able to participate.
- REPLICATION COHORT: Individuals who were affected sporadic singleton cases of aneurysms (i.e. without a family history) under the age of 40; OR an individual of any age who was diagnosed with more than one IBA, will also be recruited as the "Replication Cohort". Genetic studies of this nature will also validate the applicability of our findings to members of the general population who have non-familial brain aneurysms.
- Individuals not affected with intracranial berry aneurysms and with no family history will not be recruited.
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