Research Study

A Phase I Study: Low-Dose Total Lymphoid Irradiation in the Treatment of Refractory Chronic Graft Versus Host Disease
Principal Investigator 
Raewyn Broady


Body Locations and Systems 
Immune System and Disorders 
Study Start/End 
Apr 23, 2015 to Aug 12, 2020
Vancouver General Hospital
Myra San Antonio, Research Coordinator
604-875-4111 ext.69277
Purpose of Study 

This phase I trial studies the side effects and best dose of low-dose total lymphoid irradiation (LD-TLI) in treating patients with chronic graft-versus-host disease that has not responded to treatment with steroids. LD-TLI is a procedure in which all of the body's major lymph nodes are treated with small doses of radiation in order to reset the dysfunctional immune system. LD-TLI may work as a treatment for graft-versus-host disease caused by a bone marrow or stem cell transplant.


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