Anna M. Celler

Medical Physicist
Degrees / Designations 

MSc, PhD, FCCPM

Email Address 
Phone 
604-875-5252
Mailing Address 
Medical Imaging Research Group VGH Research Pavilion #366-828 West 10th Avenue Vancouver, B.C, V5Z 1L8

Biography

Academic Appointment 
Professor
Other Areas of Research 
Medical Physics
Nuclear Physics
Medical Imaging

Anna Celler is a professor in the Department of Radiology at the University of British Columbia (UBC) Vancouver, Canada. She is also the Head of the Medical Imaging Research Group (MIRG), associated with the Vancouver Coastal Health Research Institute, an Adjunct Professor at the Department of Mathematics, Simon Fraser University and an Associate Member at the Department of Physics and Astronomy, UBC. Dr. Celler’s main expertise is in nuclear and medical physics, quantitative and dynamic image reconstruction and analysis, dosimetry for radionuclide therapies, cyclotron production of medical radioisotopes and use of sophisticated mathematics in different aspects of imaging. She is the author of more than 350 peer-reviewed articles, abstracts and book chapters and serves on many committees and review boards.

Current Projects 
  • Quantitative SPECT Imaging. MIRG extensive research on attenuation correction, the Klein-Nishina based scatter correction (APD), resolution recovery and partial volume corrections resulted in development of a fully quantitative (qSPECT, absolute accuracy 95%) reconstruction method for many isotopes used in diagnostic imaging. The method is currently being expanded onto isotopes used in radionuclide therapy and forms the basis of our analytical dosimetry calculations (with Pomeranian Medical University, Szczecin, POLATOM, Swierk and Millitary Institute of Medicine, Warsaw, Poland).
  • Dynamic Reconstruction. Our quantitative image reconstruction was extended into the fourth, temporal dimension resulting in a novel method (patent granted) that allows us to obtain quantitative information about kinetic processes in the body from the data acquired using a standard rotating SPECT/CT systems, PET/CT and stationary multipinhole SPECT (with Ottawa Heart Inst., Ottawa).
  • Compton Camera Project. Stochastic origin ensembles 3D algorithm has been used for image reconstruction from the data acquired by collimator-less (Compton) camera. Expectation maximization based resolution recovery significantly improves images (with Harvard Medical School, Boston, USA).
  • Dual Isotope PET.  A novel method for reconstruction of two separate images from a simultaneous acquisition of two PET radiotracers (one pure position-emitter, the second position-gamma emitter) has been proposed with important clinical applications (with University of Washington, Seattle, USA).
  • Dual Isotope SPECT. MIRG qSPECT reconstruction method with APD scatter correction forms the basis of our dual-isotope SPECT imaging (with Centre Hospitalier de Bigorre, Tarbes, France).
  • Functional Imaging for Optimization of Radiotherapy Planning. A prospective study to optimize radiotherapy planning for lung cancer by incorporating functional lung imaging into radiotherapy planning using co-registered SPECT/CT with CT-simulator planning images. SPECT provides a means of creating three-dimensional (3D) maps of lung perfusion (with BCCA, Vancouver.)
  • Development of quantitative surrogate markers for evaluation of tumour progression and response to therapy. The objective is to create a framework to obtain precise quantitative measurements of (a) tumour size, (including its boundaries) and (b) quantitative radiotracer uptake (determination of total and voxelized uptake) taking into account the anatomical information from the morphological image and the imaging characteristics of the instruments (with BCCA, Vancouver).
  • Dosimetry for internal radiotherapy for beta-emitting radioisotopes. This research aims at creation of a practical and clinically useful method for individualized dosimetry for radionuclide therapies with 90Y and 188Re microspheres for liver tumours and single or mixed radioisotopes therapies with 177Lu and 90Y for neuroendocrine tumours (with BCCA and Vancouver Coastal Health, Pharmaceutical Sciences, UBC, Vancouver, Pomeranian Medical University, Szczecin, POLATOM, Swierk, Millitary Institute of Medicine, Medical Centre for Postgraduate Education, Warsaw, Poland).
  • Cyclotron production of medical radioisotopes. Theoretical calculations of cross sections and reaction yields for cyclotron production of medically relevant radioisotopes (99mTc and others) are being performed to predict optimum production conditions and estimate dosimetry. In particular, 99mTc obtained using reactor- and cyclotron-based approaches have been compared (with BCCA, Nuclear Medicine Division-TRIUMF, Pharmaceutical Sciences, UBC & many other Canadian collaborators).
Publications