Having trained in systems biology and medical biotechnology as well as in biochemistry and drug discovery, my current research interests include utilizing the knowledge of the “-omics” in designing novel treatment options for cancer and the use of state-of-the-art high-throughput technologies to identify novel targets and to repurpose old drugs for cancer treatment. My goal is also to find better ways to utilize current genome-wide technologies in designing personalized treatment options. Especially I am interested in the molecular mechanisms of treatment resistance such as the activation of antioxidative defence mechanisms during drug induced epithelial-to-mesenchymal transition and accumulation of cancer stem cells. Currently, my projects focus on the mechanisms of castrate- and anti-androgen resistance as well as targeting the resistance pathways in prostate cancer.
Targeting Treatment Resistance in Prostate Cancer
- PloS one - 2012, Dec 19
- British journal of cancer - 2012, Jan 4
- Molecular cancer therapeutics - 2010, Dec 16
- Clinical cancer research : an official journal of the American Association for Cancer Research - 2009, Oct 2
- Oncotarget - 2013, Mar 1