Single-molecule Insights for Therapeutic Discovery, Development and Diagnostics: The Next Level of Resolution

Join the UBC Department of Pathology and Laboratory Medicine for a presentation by Dr. Sabrina Leslie, which will delve into the following insights:

• New tether-free Convex Lens-induced Confinement (CLiC) imaging technology allows DNA, RNA, protein molecules to be imaged one at a time
• The interactions and dynamics of these molecules can be visualized and quantified in real time and in response to changes in environment, allowing new insights to be obtained into mechanisms of action 
• Direct characterization of the size and mRNA payloads of lipid nanoparticle delivery vehicles can also be achieved
• Perturbing the solution environment and observing the dynamics of the nanoparticles, such as fusion or release, allows mechanisms of delivery to be investigated
• Furthermore visualizing single molecules inside living cells, using the same CLiC platform, allows for new insights to be obtained "from the single cell level and down", thus marrying experiments with "biological complexity" (single cells and up) with biophysical rigour (single molecules)

Attend via Zoom
Meeting ID: 611 9907 6992
Passcode: 192510