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  3. Sriram Subramaniam

Sriram Subramaniam

Professor
Academic Appointment
Professor
Contact Info
electron.med.ubc.ca/
sriram.subramaniam@ubc.ca
cryoem_UBC
sriramsubramaniam/

Biography

Dr. Sriram Subramaniam is Gobind Khorana Chair in Cancer Drug design at the University of British Columbia and also the founder and CEO of Gandeeva Therapeutics. Prior to his arrival in Vancouver, he was senior investigator at the National Institutes of Health where he also founded and directed the US National Cryo-EM Facility. He received his PhD in physical chemistry from Stanford University and completed postdoctoral training in the Departments of Chemistry and Biology at the Massachusetts Institute of Technology. 

Dr. Subramaniam is recognized internationally for his leadership in driving the cryogenic electron microscopy (cryo-EM) resolution revolution. His work showed for the first time that the structures of proteins, bound drugs as well as variety of dynamic protein complexes could be visualized using cryo-EM methods at near-atomic resolution. Dr. Subramaniam and his group have continued to remain at the forefront of the cryo-EM field with innovations in technology for imaging and applications to important biomedical problems.

News and Awards

Zooming in on COVID-19 Alpha variant

Jul 7, 2021

Publications

  • Nature methods -

    A paradigm shift in structural biology.

    Subramaniam S, Kleywegt GJ
  • Science (New York, N.Y.) -

    SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein-ACE2 complex.

    Mannar D, Saville JW, Zhu X, Srivastava SS, Berezuk AM, Tuttle KS, Marquez AC, Sekirov I, Subramaniam S
  • Nature communications -

    Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants.

    Saville JW, Mannar D, Zhu X, Srivastava SS, Berezuk AM, Demers JP, Zhou S, Tuttle KS, Sekirov I, Kim A, Li W, Dimitrov DS, Subramaniam S
  • Cell reports -

    Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding.

    Mannar D, Saville JW, Zhu X, Srivastava SS, Berezuk AM, Zhou S, Tuttle KS, Kim A, Li W, Dimitrov DS, Subramaniam S
  • eLife -

    A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor.

    Huang Y, Ognjenovic J, Karandur D, Miller K, Merk A, Subramaniam S, Kuriyan J
  • The Journal of biological chemistry -

    AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation.

    Caffrey B, Zhu X, Berezuk A, Tuttle K, Chittori S, Subramaniam S
  • Current opinion in structural biology -

    New insights into Raf regulation from structural analyses.

    Kondo Y, Paul JW, Subramaniam S, Kuriyan J
  • PLoS biology -

    Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies.

    Zhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S
  • Nature structural & molecular biology -

    Cryo-EM structures reveal coordinated domain motions that govern DNA cleavage by Cas9.

    Zhu X, Clarke R, Puppala AK, Chittori S, Merk A, Merrill BJ, Simonović M, Subramaniam S
  • Science (New York, N.Y.) -

    Structural mechanisms of centromeric nucleosome recognition by the kinetochore protein CENP-N.

    Chittori S, Hong J, Saunders H, Feng H, Ghirlando R, Kelly AE, Bai Y, Subramaniam S
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