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  1. Home
  2. Our Research
  3. Syam Somasekharan

Syam Somasekharan

Assistant Professor
Academic Appointment
Assistant Professor
Degrees / Designations
PhD
Contact Info
syam@mail.ubc.ca
604-875-4111 ext.21758

Biography

Dr. Syam Somasekharan is an assistant professor at the University of British Columbia (UBC) and a senior research scientist at the Vancouver Prostate Centre. Graduating with a PhD in biochemistry at the Indian Institute of Science, Dr. Somasekharan proceeded to do his post-doctoral fellowships at the Department of Cell Biology, University of Geneva and the Department of Pathology, UBC, investigating the molecular mechanisms of apoptosis and mRNA translation. After his post-doctoral research, Dr. Somasekharan received the Early Career Research Award from the Government of India and served as a Ramanujan Fellow at the Indian Institute of Technology, Indore. 

Dr. Somasekharan’s laboratory is located at the Vancouver Prostate Centre and focuses on RNA biology. The laboratory is particularly interested in interdisciplinary research to understand the molecular mechanism of regulation of RNA in health and disease. In 2023, he received federal NSERC Discovery Grant funding for his research investigating the role of RNA-binding motif protein X-linked 2 (RBMX2) in nucleolar phase separation and functions. He is also the recipient of a 2023 Prostate Cancer Research Program Idea Development Award - Established Investigator Award from the U.S. Department of Defense Congressionally Directed Medical Research Programs.

News and Awards

VCHRI SPARKS 2024 recipients

Jun 3, 2024

Publications

  • Nucleic acids research -

    Regulation of AR mRNA translation in response to acute AR pathway inhibition.

    Somasekharan SP, Saxena N, Zhang F, Beraldi E, Huang JN, Gentle C, Fazli L, Thi M, Sorensen PH, Gleave M
  • FEBS letters -

    SARS-CoV-2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid droplets.

    Somasekharan SP, Gleave M
  • Journal of proteomics -

    SILAC-based quantitative MS approach reveals Withaferin A regulated proteins in prostate cancer.

    Kumar R, Nayak D, Somasekharan SP
  • Nucleic acids research -

    G3BP1-linked mRNA partitioning supports selective protein synthesis in response to oxidative stress.

    Somasekharan SP, Zhang F, Saxena N, Huang JN, Kuo IC, Low C, Bell R, Adomat H, Stoynov N, Foster L, Gleave M, Sorensen PH
  • Nature structural & molecular biology -

    Co-translational assembly of proteasome subunits in NOT1-containing assemblysomes.

    Panasenko OO, Somasekharan SP, Villanyi Z, Zagatti M, Bezrukov F, Rashpa R, Cornut J, Iqbal J, Longis M, Carl SH, Peña C, Panse VG, Collart MA
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