Overview
Start/End Dates
Locations
Gordon and Leslie Diamond Health Care Centre
Name/Title
Ngaire Meadows, Study Coordinator
Phone
Email Address
Purpose of Study
The purpose of this study is to evaluate evogliptin for aortic stenosis (AS). AS is caused by progressive thickening and calcification of the aortic valve leaflets which leads to a reduction in aortic valve opening. Valve replacement is currently the only known treatment for this condition once it becomes severe enough to cause symptoms. No treatment has been found to date that can delay the progression of this disease. Evogliptin is a medication in a class of drugs (DPP4 inhibitors) used to treat type 2 diabetes and has been shown to slow down aortic valve calcification in tissue culture and animal models, as well as a small retrospective human study. This randomized, placebo-controlled, double-blind trial will assess the efficacy and safety of this medication for the condition.
Disclaimer
Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers and email addresses are provided for obtaining additional information on specific research studies only. If you have specific questions which require clinical expertise, please call your primary care physician.
The purpose of this study is to evaluate evogliptin for aortic stenosis (AS). AS is caused by progressive thickening and calcification of the aortic valve leaflets which leads to a reduction in aortic valve opening. Valve replacement is currently the only known treatment for this condition once it becomes severe enough to cause symptoms. No treatment has been found to date that can delay the progression of this disease. Evogliptin is a medication in a class of drugs (DPP4 inhibitors) used to treat type 2 diabetes and has been shown to slow down aortic valve calcification in tissue culture and animal models, as well as a small retrospective human study. This randomized, placebo-controlled, double-blind trial will assess the efficacy and safety of this medication for the condition.
Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers and email addresses are provided for obtaining additional information on specific research studies only. If you have specific questions which require clinical expertise, please call your primary care physician.
