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  3. Blood, Heart and Circulation

Blood, Heart and Circulation

Recruiting

Promoting sleep quality in chronic stroke with exercise

The purpose of the study is to determine whether a 26-week exercise training program or cognitive training program can improve sleep quality in stroke survivors who are experiencing poor sleep quality.

Status
Recruiting
Principal Investigator
Teresa Liu-Ambrose
Body Locations and Systems
Stroke
Bones, Joints and Muscles
Brain and Nerves
Age
55 and above

Investigating blood thinners for atrial fibrillation after surgery

The purpose of this study is to assess the effects of blood thinners in patients who develop short-term atrial fibrillation during surgery, and to determine whether blood thinners can lower the risk of stroke in this population. 

Status
Recruiting
Body Locations and Systems
Blood, Heart and Circulation
Arrhythmia
Atrial Fibrillation
Age
55 and above

Investigating treatment for patients with chronic graft-versus-host disease

The purpose of this study is to evaluate the safety, tolerability and preliminary activity of axatilimab in combination with ruxolitinib and to assess the contribution of axatilimab to the combination treatment effect in participants with chronic graft-versus-host disease.

Status
Recruiting
Principal Investigator
Jennifer White
Body Locations and Systems
Blood, Heart and Circulation
Immune System
Age
12 and above

Evaluating the efficacy of evogliptin for aortic stenosis

The purpose of this study is to evaluate evogliptin for aortic stenosis (AS). AS is caused by progressive thickening and calcification of the aortic valve leaflets which leads to a reduction in aortic valve opening. Valve replacement is currently the only known treatment for this condition once it becomes severe enough to cause symptoms. No treatment has been found to date that can delay the progression of this disease.

Status
Recruiting
Principal Investigator
Christina Luong
Body Locations and Systems
Blood, Heart and Circulation
Age
35 and above

Testing non-invasive spinal cord stimulation for early spinal cord injury

The purpose of this study is to investigate the safety and effectiveness of non-invasive transcutaneous spinal cord stimulation (TSCS) in conjunction with conventional rehabilitation in helping with the recovery of bladder function in persons with spinal cord injury (SCI). The study team will assess immediate TSCS efficacy when the stimulation is turned on, as well as the persisting effects of TSCS (e.g. any changes in function) that remain after the stimulation is turned off and after several weeks of regular stimulation.

Status
Recruiting
Principal Investigator
Andrei Krassioukov
Body Locations and Systems
Blood, Heart and Circulation
Brain and Nerves
Spinal Cord Injury
Kidneys and Urinary System
Bladder
Sexual Health
Age
19-65

Understanding the experiences of young women stroke survivors

The purpose of this study is to identify gaps in health services and make recommendations for the development of high-quality and equitable systems of stroke care informed by young women stroke survivors' experiences.

To participate in this study, complete the online form.

Status
Recruiting
Principal Investigator
Sally Thorne
Body Locations and Systems
Stroke
Brain and Nerves
Age
18-60

Evaluating a study drug in participants with heart failure and pulmonary hypertension

The purpose of this study is to evaluate the efficacy, safety and pharmacokinetics of study drug AZD3427 in addition to standard of care in participants with heart failure and pulmonary hypertension due to left heart disease (World Health Organization Group 2).

Status
Recruiting
Principal Investigator
Margot Davis
Body Locations and Systems
Blood, Heart and Circulation
Age
19 and above

Understanding the experiences of relocated transplant patients

The purpose of this study is to understand and document the experiences of patients who live at least 60 minutes outside of the Lower Mainland and who are traveling to Vancouver for a solid organ transplant. The research team aims to document the psychological, social, emotional and cultural impact for patients leaving their communities to access care in Vancouver. The study will also capture the associated out-of-pocket costs that these transplant patients incur before, during and after the transplant operation.

Status
Recruiting
Principal Investigator
Jude Kornelsen
Body Locations and Systems
Blood, Heart and Circulation
Digestive System
Kidneys and Urinary System
Lungs and Breathing

Collecting data for the Pacific Parkinson’s Research Centre Biobank

The purpose of this study is to collect biospecimens (fecal, urine, blood) and clinical data to serve as a resource for future research on Parkinson’s disease and other movement disorders. The careful collection, storage and retrieval of biospecimens and medical information for research projects are critical for improving understanding of healthy development and disease mechanisms and the subsequent development of effective treatments. Biospecimens from this biobank will be made available for ethically-approved studies.

Status
Recruiting
Principal Investigator
Silke Appel-Cresswell
Body Locations and Systems
Blood, Heart and Circulation
Brain and Nerves
Parkinson's Disease
Digestive System
Immune System
Kidneys and Urinary System
Mouth and Teeth
Age
19 and above

Testing the effectiveness of cardiac resynchronization therapy in heart failure

The purpose of this study is to test the comparative effectiveness of two types of cardiac resynchronization therapy (CRT) lead implantations (His vs LBBP) in relation to patient-centered outcomes (e.g. quality of life, physical activity, heart failure hospitalization, mortality) and comparative safety in relation to device-related complications and re-interventions (e.g. lead dislodgement, infection) relative to standard of care biventricular pacing.

Status
Recruiting
Principal Investigator
Jason Andrade
Body Locations and Systems
Blood, Heart and Circulation
Heart Failure
Age
18 or above

Investigating non-invasive spinal cord stimulation for autonomic function recovery

The purpose of this study is to investigate the effects of non-invasive transcutaneous spinal cord stimulation (TCSCS) on cardiovascular, bladder, bowel and sexual function in people with spinal cord injury. The study team is interested in the immediate, long-term and longer-term effects (eight weeks after cessation of therapy) of non-invasive stimulation on these functions.

Status
Recruiting
Principal Investigator
Andrei Krassioukov
Body Locations and Systems
Blood, Heart and Circulation
Brain and Nerves
Kidneys and Urinary System
Men's and Women's Health
Age
18-60

Exploring impact of clinical trial participation on multiple myeloma outcomes

The purpose of this study is to explore the differences in socioeconomic and demographic factors between clinical trial participants and non-participants, and to explore whether clinical trial participation influences overall clinical outcomes. This is a retrospective chart review that will collect sociodemographic and economic factors of all multiple myeloma patients and identify differences between clinical trial participants and non-participants, as well as analyze whether clinical trial participation influenced clinical outcomes of these patients.

Status
Recruiting
Body Locations and Systems
Blood, Heart and Circulation

Evaluating the safety of a new drug to reduce heart disease symptoms

The purpose of this study is to test a potential new medicine, NNC6019-0001, for people who have heart disease due to transthyretin (TTR) amyloidosis. The study will compare the new medicine at two dose levels (10 mg/kg and 60 mg/kg) to placebo on change in a 6-minute walk test and N-terminal pro-brain natriuretic peptide (NT-proBNP) test from baseline to week 52, or occurrence of death or cardiovascular hospitalization, in participants with hereditary transthyretin amyloidosis or wild-type transthyretin amyloid cardiomyopathy.

Status
Recruiting
Principal Investigator
Margot Davis
Body Locations and Systems
Blood, Heart and Circulation
Age
18-85

Testing a drug treatment to reduce major adverse cardiac events

The purpose of this study is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor. The primary outcome, MACE, is a composite of first occurrence of cardiovascular death, non-fatal sudden cardiac arrest, cardiogenic shock, significant ventricular arrythmias, significant bradyarrythmias or incident heart failure.

Status
Recruiting
Principal Investigator
Margot Davis
Body Locations and Systems
Blood, Heart and Circulation
Age
18 and above

Comparing treatments for newly diagnosed multiple myeloma patients

The purpose of this study is to compare the standard of care therapy (VRd + Rd therapy) and CAR-T therapy (VRd + CAR-T) for newly diagnosed multiple myeloma patients who do not plan to receive hematopoietic stem cell transplant as initial therapy.

Status
Recruiting
Principal Investigator
Kevin Song
Body Locations and Systems
Blood, Heart and Circulation
Age
18 and above

Evaluating the safety of an ultrasound-guided vascular closure device

The purpose of this study is to collect real-world data on the safety and efficacy of the MANTA vascular closure device using ultrasound guidance in stopping blood flow/close catheter access sites at the end of large-bore interventional cardiology procedures compared to using pre-procedural depth locator measurements.

Status
Recruiting
Principal Investigator
David Wood
Body Locations and Systems
Blood, Heart and Circulation
Age
21 and above

Treating post-thrombotic syndrome with micronized purified flavonoid fraction

The purpose of this study is to determine whether a 6-month course of oral micronised purified flavonoid fraction (MPFF), compared with placebo, improves the symptoms and signs of post-thrombotic syndrome (PTS) and quality of life at six months follow-up.

Status
Recruiting
Principal Investigator
Agnes Lee
Body Locations and Systems
Blood, Heart and Circulation
Age
18 and above

Comparing ablation strategies to treat atrial fibrillation

The purpose of this study is to collect information to determine if some ablation strategies work better than others for treating atrial fibrillation.

Status
Recruiting
Principal Investigator
Jason Andrade
Body Locations and Systems
Blood, Heart and Circulation
Age
19 and above

Assessing the impact of a study drug to reduce cardiovascular risk

The purpose of this study is to support an indication of inclisiran for the reduction of cardiovascular risk in participants with established atherosclerotic cardiovascular disease who have elevated low-density lipoprotein cholesterol levels despite being on a background of well-tolerated dose of a high-intensity statin therapy. 

Status
Recruiting
Principal Investigator
G.B. John Mancini
Body Locations and Systems
Blood, Heart and Circulation
Age
40 and above

Optimizing drug treatment for chronic myelogenous leukemia

The purpose of this study is to optimize the treatment of asciminib in patients with chronic myelogenous leukemia in chronic phase (CML-CP), who have previously been treated with at least 2 tyrosine kinase inhibitors. Additionally, this study will investigate the usage of two different dosing regimes of asciminib, 80mg daily and 40mg twice daily.

Status
Recruiting
Principal Investigator
Donna Forrest
Body Locations and Systems
Blood, Heart and Circulation
Age
18 and above

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