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  3. Testing the effectiveness of cardiac resynchronization therapy in heart failure
Research Study

Cardiac Resynchronization Therapy Using His/Left Bundle Branch Pacing vs Biventricular Pacing with a Left Ventricular Epicardial Lead in Patients with Heart Failure (HF) with Left Ventricular Ejection Fraction (LVEF) ≤ 50% and with either a Wide QRS Complex (greater than 130 ms) or with/anticipated greater than 40% Pacing Randomized Clinical Trial (RCT)

Principal Investigator
Jason Andrade

Overview

Body Locations and Systems
Blood, Heart and Circulation
Heart Failure
ClinicalTrials.gov#
NCT05650658
Status
Recruiting
Start/End Dates
Mar 1, 2024 Nov 30, 2030
Locations
Gordon and Leslie Diamond Health Care Centre
Vancouver General Hospital
Name/Title
Yannick Munyura, Clinical Research Coordinator
Phone
604-220-9307
Email Address
yannick.munyura@ubc.ca
Purpose of Study

The purpose of this study is to test the comparative effectiveness of two types of cardiac resynchronization therapy (CRT) lead implantations (His vs LBBP) in relation to patient-centered outcomes (e.g. quality of life, physical activity, heart failure hospitalization, mortality) and comparative safety in relation to device-related complications and re-interventions (e.g. lead dislodgement, infection) relative to standard of care biventricular pacing. This will be studied in patients with heart failure due to left ventricular systolic dysfunction (LVEF ≤50%) and with either a wide QRS (≥130 ms) or  >40% pacing who are already receiving current standard heart failure pharmacological therapy.

Study participants will be randomly assigned to one of two treatments, both of which are standard of care heart pacing treatments but in slightly different anatomical locations in the heart. After the procedure participants will be followed for 60 months.

Eligibility

Visit ClinicalTrials.gov for more information.

Disclaimer

Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers and email addresses are provided for obtaining additional information on specific research studies only. If you have specific questions which require clinical expertise, please call your primary care physician.

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