Skip to main content

Main menu

  • About Us
    • Leadership
    • Our Team
    • Vision, Mission and Values
    • Health and Economic Impact
    • Research Impact Video
    • Strategic Plan
  • Our Research
    • Research Focus
      • Brain Health
      • Cancer
      • Digital Health and Artificial Intelligence
      • Heart Health
      • Healthy Aging and Mobility
      • Immune System
      • Injury and Rehabilitation
      • Lung Health
      • Mental Health and Substance Use
    • Research Centres and Programs
      • BC Centre on Substance Use
      • Centre for Aging SMART
      • Centre for Cardiovascular Innovation
      • Centre for Clinical Epidemiology and Evaluation
      • Centre for Lung Health
      • Djavad Mowafaghian Centre for Brain Health
      • Immunity and Infection Research Centre
      • International Collaboration On Repair Discoveries
      • M. H. Mohseni Institute of Urologic Sciences
      • Ovarian Cancer Research Centre
      • Community Research Program
      • Emergency Medicine Research Program
      • Hematology Research Program
      • Skin Research Program
      • Other Research Focus Areas
    • News and Stories
    • Researcher Directory
    • Events and Workshops
  • Research Services
    • New to VCHRI
      • Working at VCHRI
      • Regulations and Training
      • Membership with VCHRI
      • Learning and Development
    • Starting Your Project
      • Research Facilitation
      • Awards and Funding
      • Grant Management
      • Operational Approval
      • CST Cerner
    • Developing Your Project
      • Clinical Trials Administration
      • Clinical Research Unit
      • Research Privacy
      • Financial Policies and Procedures
    • Additional Support
      • Indigenous Health Research Unit
      • VCH-VCHRI AI Hub
      • Communications and Media Relations
      • Study Recruitment Support
      • Innovation and Industry Partnership
    • Internal Awards
    • Clinical Research
    • Indigenous Research
  • Participate in Research
    • Reasons to Participate
    • Participant Stories
    • Find a Study
    • Recruitment Support

User menu

  • Log in

Breadcrumb

  1. Home
  2. Participate in Research
  3. Evaluating the efficacy of evogliptin for aortic stenosis
Research Study

EVOID-AS: An Adaptive 2/3 Multicentre, Double-blind, Placebo-controlled, Randomized, Parallel 3 Arm Study to Evaluate the Efficacy and Safety of DA-1229 (Evogliptin) in Patient's Calcific Aortic Valve Disease with Mild to Moderate Aortic Stenosis

Principal Investigator
Christina Luong

Overview

Body Locations and Systems
Blood, Heart and Circulation
ClinicalTrials.gov#
NCT05143177
Status
Recruiting
Start/End Dates
Jun 1, 2025
Locations
Gordon and Leslie Diamond Health Care Centre
Name/Title
Ngaire Meadows, Study Coordinator
Phone
604-875-4065
Email Address
ngaire.meadows2@vch.ca
Purpose of Study

The purpose of this study is to evaluate evogliptin for aortic stenosis (AS). AS is caused by progressive thickening and calcification of the aortic valve leaflets which leads to a reduction in aortic valve opening. Valve replacement is currently the only known treatment for this condition once it becomes severe enough to cause symptoms. No treatment has been found to date that can delay the progression of this disease. Evogliptin is a medication in a class of drugs (DPP4 inhibitors) used to treat type 2 diabetes and has been shown to slow down aortic valve calcification in tissue culture and animal models, as well as a small retrospective human study. This randomized, placebo-controlled, double-blind trial will assess the efficacy and safety of this medication for the condition. 

Disclaimer

Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers and email addresses are provided for obtaining additional information on specific research studies only. If you have specific questions which require clinical expertise, please call your primary care physician.

Share

  • Facebook
  • Linkedin
  • Twitter
  • Email

Get updates!

Join our newsletter mailing list to stay up to date on features and releases.

Subscribe

Quick Links

  • News and Stories
  • Careers
  • Events
  • Media Enquiries

Follow Us

  • LinkedIn
  • X
  • YouTube

© 2025 VCHRI. All rights reserved.

  • Contact
  • Privacy Policy