Comparing ablation strategies to treat atrial fibrillation
The purpose of this study is to collect information to determine if some ablation strategies work better than others for treating atrial fibrillation.
Status
Recruiting
Recruiting
Assessing the impact of a study drug to reduce cardiovascular risk
The purpose of this study is to support an indication of inclisiran for the reduction of cardiovascular risk in participants with established atherosclerotic cardiovascular disease who have elevated low-density lipoprotein cholesterol levels despite being on a background of well-tolerated dose of a high-intensity statin therapy.
Status
Recruiting
Optimizing drug treatment for chronic myelogenous leukemia
The purpose of this study is to optimize the treatment of asciminib in patients with chronic myelogenous leukemia in chronic phase (CML-CP), who have previously been treated with at least 2 tyrosine kinase inhibitors. Additionally, this study will investigate the usage of two different dosing regimes of asciminib, 80mg daily and 40mg twice daily.
Status
Recruiting
Comparing treatment for atrial fibrillation in the emergency department
The purpose of this study is to compare standard treatment against a newly approved medication for patients presenting to the emergency department with a heart condition called atrial fibrillation. A sub-study will also look at a new consenting process in the emergency department and the experience of patients with this consent process.
Status
Recruiting
Advancing cardiac care-based rapid assessment and treatment of high cholesterol
The purpose of this study is to understand the ability of genetic testing to identify familial hypercholesterolemia among patients with acute cardiac event in hospital settings and to investigate the impact of genetic diagnosis on physician behaviour, medication use and decreasing cholesterol to an acceptable level.
Status
Recruiting
Automated detection of autonomic dysreflexia via deep learning
The purpose of this study is to investigate if and how retinal blood vessels change after a spinal cord injury (SCI) and the associations of these changes with cardiovascular diseases. Using images of retinal blood vessels, we will develop a deep learning-based screening tool for autonomic dysreflexia, a cardiovascular complication unique to SCI.
Status
Recruiting
PD Hypotension Study
The purpose of this study is to investigate whether Electrical Vestibular Stimulation (EVS) can lessen orthostatic hypotension in Parkinson’s disease patients. We aim to determine if individual precision-designed EVS stimulus can be optimized for improvements in hypotension.
Status
Recruiting
Long-Term Follow-up Protocol for Subjects Treated With Gene-Modified T Cells
The purpose of this study it to examine the safety and efficacy of gene-modified T cell therapy in patients who have previously received the treatment.
Status
Recruiting
CAN-ACCESS
The purpose of the study is to find the best technique and tools for gaining access to left and right heart arteries using x-rays that show blood flow, in patients who are having a specific Medtronic heart valve inserted.
Status
Recruiting
Dapagliflozin and Effect on Cardiovascular Events in Acute Heart Failure -Thrombolysis in Myocardial Infarction 68 (DAPA ACT HF-TIMI 68)
The purpose of the study is to evaluate the effect of in-hospital initiation of dapagliflozin versus placebo on the clinical outcome of cardiovascular death or worsening heart failure.
Status
Recruiting
A Study of CC-97540, CD19-targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, in Subjects With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
The purpose of this study is to evaluate the safety and efficacy of CC-97540 CAR-T cell treatment for subjects with relapsed or refractory B-cell non-Hodgkin lymphoma.
Status
Recruiting
Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE)
The purpose of the study is to compare differences in blood flow and valve pressures by two different methods in patients who are having transcatheter aortic valve replacement.
Status
Recruiting
An Efficacy Study Comparing Ponatinib Versus Imatinib, Administered in Combination With Reduced-Intensity Chemotherapy, in Participants With Newly Diagnosed Ph+ ALL
The purpose of this study is to compare the efficacy of the drugs ponatinib versus imatinib, administered as first-line therapy in combination with reduced-intensity chemotherapy, in participants with newly diagnosed Ph+ ALL, as measured by the minimal residual disease (MRD)-negative complete remission (CR) at the end of induction.
Status
Recruiting
A Study of MBG453 in Combination With Azacitidine and Venetoclax in AML Patients Unfit for Chemotherapy (STIMULUS-AML1)
The purpose of this study is to investigate the safety and efficacy of the drug MBG453 as treatment for newly diagnosed Acute Myeloid Leukemia patients when used in combination with other anti-cancer treatments.
Status
Recruiting
Blinatumomab for MRD in Pre-B ALL Patients Following Stem Cell Transplant
The purpose of this study is to determine whether treatment with Blinatumomab is effective in reducing the risk of acute lymphoblastic leukemia returning in patients with residual cancer cells remaining in the body after stem cell transplant.
Status
Recruiting
Creation and Implementation of a BC/Canada Registry for Familial Hypercholesterolemia
Familial hypercholesterolemia (FH) is the most frequent genetic lipoprotein disorder associated with premature coronary artery disease. The goal of this initiative is to create a registry of subjects with FH across Canada. The registry will help clinicians and researchers to determine the burden of disease and the long-term effects of treatment.
Status
Recruiting
MANTA Vascular Closure Device Clinical Study (MANTA)
Research study which tests the safety and effectiveness of a new vascular closure device to close the femoral access puncture that is created in patients who require this form of access in order to perform the planned procedure. The MANTA device is expected to seal the femoral access puncture in less than 1 minute. This may result in less blood loss and a shorter time to walking compared to alternative closure means. Use of the MANTA device in this study is experimental. All other parts of the procedure involve standard medical care
Status
Recruiting
PULSE (Partners Using Linked Strategies Effectively) Study
Health behaviors like physical activity and nutritious eating habits significantly reduce initial stroke risk and help prevent strokes from reoccurring. Yet, most individuals struggle to meet physical activity and nutrition recommendations. Health and health behaviors are typically linked in couples, and spouses occupy a unique position to facilitate each other’s physical activity and healthy nutrition, thereby reducing stroke risk for everyone involved.
Status
Recruiting
Using imaging to aid heart attack diagnosis
The purpose of this study is to employ standardized imaging protocols in women and men with MINOCA (MI with Non Obstructive Coronary Arteries) to determine the underlying diagnosis in each participant. Participants will be followed for recurrent clinical events, every six months, for a maximum of 10 years.
Status
Recruiting
AMPLATZER™ LAA Occluder Post Approval Study (PAS)
The AMPLATZER LAA Occluder is a transcatheter, self-expanding nitinol device intended for use in preventing thrombus embolization from the LAA. The purpose of this study is to compile real world outcome data on the use of AMPLATZER LAA Occluder in subjects with non-valvular atrial fibrillation (NVAF)
Status
Recruiting