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  3. Heart Disease

Heart Disease

Recruiting

Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE)

The purpose of the study is to compare differences in blood flow and valve pressures by two different methods in patients who are having transcatheter aortic valve replacement.

Status
Recruiting
Principal Investigator
David Wood
Body Locations and Systems
Heart Disease
Area
Vancouver

Resynchronization/Defibrillation for Ambulatory Heart Failure Trial in Patients With Permanent Atrial Fibrillation (RAFT-PermAF)

Atrial fibrillation (AF) and heart failure (HF) are two common heart conditions that are encountered with an increase in death and suffering. When both these two conditions occur in a patient, the patient's prognosis is poor with a reduced quality of life. These patients are frequently admitted to the hospital and have increased risk of death. In these HF patients who are in AF all of the time, who would otherwise be a suitable candidate for an implantable defibrillator to prevent sudden cardiac death, whether adding pacing of both ventricles will reduce death and suffering.

Status
Recruiting
Principal Investigator
Matthew Bennett
Body Locations and Systems
Heart Failure
Atrial Fibrillation
Heart Disease
Area
Vancouver
Age
18 and above

Statin and Angiotensin-converting Enzyme Inhibitor on Symptoms in Patients With SCAD (SAFER-SCAD)

An emerging cause of heart attack in young women is a dissection (or tear) in the coronary arteries. Many of these young women continue to have chest pain long after the tear has healed and this is thought to be due to problems with their small blood vessels of the heart (or microcirculation). We want to determine whether commonly used medications for coronary artery disease including statins (for cholesterol) and angiotensin-converting enzyme inhibitors (for blood pressure) reduce chest pain and improve small vessel function in these patients.

Status
Recruiting
Principal Investigator
Tara Sedlak
Body Locations and Systems
Heart Disease
Area
Vancouver

Closed for Recruitment

A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High Risk Patients With Hypertriglyceridemia and on Statin (REDUCE-IT)

AMR101 (icosapent ethyl [ethyl-EPA]) is a highly purified ethyl ester of eicosapentaenoic acid (EPA) being developed by Amarin Pharma Inc. for the treatment of hypertriglyceridemia. The purpose of this study is to evaluate whether this drug, combined with a statin therapy, will be superior to the statin therapy alone, when used as a prevention in reducing long-term cardiovascular events in high-risk patients with mixed dyslipidemia.

Status
Closed for Recruitment
Principal Investigator
Graham Wong
Body Locations and Systems
Heart Disease
Area
Vancouver
Age
45 and above

Tailored Antiplatelet Therapy Following PCI (TAILOR-PCI)

Clopidogrel is an anti-platelet medication approved by the U.S. Federal Drug Administration (FDA) for use in patients who undergo Percutaneous Coronary Intervention (PCI) with coronary stent implantation. Anti-platelet medications work to prevent blood clots from forming. Some studies have suggested that patients who have a certain genetic liver enzyme abnormality (known as cytochrome P450 2C19 [CYP2C19] *2 or *3 allele) may have a reduced ability to activate clopidogrel, and therefore may have a lowered response to clopidogrel.

Status
Closed for Recruitment
Principal Investigator
Jacqueline Saw
Body Locations and Systems
Heart Disease
Atherosclerosis
Area
Vancouver
Age
18 and above

EXCEL Clinical Trial (EXCEL)

To establish the safety and efficacy of the commercially approved XIENCE Family Stent System (inclusive of XIENCE PRIME, XIENCE V, XIENCE Xpedition and XIENCE PRO [for use outside the United States [OUS] only]) in subjects with unprotected left main coronary artery disease by comparing to coronary artery bypass graft surgery.

Status
Closed for Recruitment
Principal Investigator
Jaap N. Hamburger
Body Locations and Systems
Heart Disease
Coronary Artery Disease
Area
Vancouver
Age
18 and above
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