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Brain and Nerves

Recruiting

Examining the cognitive effects of cannabis on stress response

The purpose of this study is to investigate the effects of cannabis in people who use recreational cannabis and meet criteria for heavy drinking. Investigators will examine the emotional and cognitive effects of cannabis oil on social and cognitive functioning.

Status
Recruiting
Principal Investigator
Christian Schütz
Body Locations and Systems
Brain and Nerves
Age
19-35

Reshaping the path of mild cognitive impairment with exercise training

The purpose of the study is to investigate the effects of different types of exercise training on cognitive function. Investigators aim to assess the individual effects of aerobic and resistance training, as well as the interaction effect of combining the two types of exercise training, on cognitive function in older adults with mild cognitive impairment.

Status
Recruiting
Principal Investigator
Teresa Liu-Ambrose
Body Locations and Systems
Brain and Nerves
Age
65-85

Studying the use of BOTOX to treat essential tremor

The purpose of this study is to to evaluate the efficacy and safety of Botulinum Toxin Type A (BOTOX) Purified Neurotoxin Complex compared to placebo for the treatment of upper limb essential tremor.

Status
Recruiting
Principal Investigator
Silke Cresswell
Body Locations and Systems
Brain and Nerves
Age
18-80

Evaluating the feasibility of non-medication treatments for depression

The purpose of this study is to explore the use of two separate non-medication treatments, light therapy and ion therapy, as substitutes for antidepressents for maintenance treatment in major depression. 

Status
Recruiting
Principal Investigator
Raymond Lam
Body Locations and Systems
Brain and Nerves
Age
19-65

Evaluating colchicine to prevent vascular events after hemorrhage

The purpose of this study is to determine if the use of colchicine, a drug that reduces inflammation, can lower the risk of having a stroke or heart attack from blood clots compared to placebo, and improve recovery in people with a recent brain bleed.

Status
Recruiting
Principal Investigator
Thalia Field
Body Locations and Systems
Blood, Heart and Circulation
Brain and Nerves
Age
18 and above

Treating depression with accelerated brain stimulation

The purpose of this study is to evaluate the efficacy of intermittent theta burst (iTBS) repetitive transcranial magnetic stimulation (rTMS) in improving depression symptoms over an accelerated treatment course of eight treatments per day for five days.

Status
Recruiting
Principal Investigator
Fidel Vila-Rodriguez
Body Locations and Systems
Brain and Nerves
Age
19-65

Using eye movements to understand cognitive and motor functions in Parkinson’s Disease

The purpose of this study is to test visual abilities and eye movements in patients with Parkinson's disease and healthy control participants and to link dysfunctions to cognitive abilities and disease severity.

Recruitment Poster

Status
Recruiting
Principal Investigator
Miriam Spering
Body Locations and Systems
Brain and Nerves
Eyes and Vision
Age
50-85

Developing an adaptive fashion guide for people with spinal cord injury

The purpose of this study is to create an adaptive clothing guide (FashionABLE) with an open-source library of clothing hacks and newly developed patterns of adaptive clothing that offers diverse, appropriate and fashion-forward clothing options that meet the functional and social needs of persons with spinal cord injury.

Status
Recruiting
Principal Investigator
Andrei Krassioukov
Body Locations and Systems
Brain and Nerves
Age
19-65

Neurocardiac predictors of treatment response to rTMS in depression

The purpose of this study is to explore whether heart rate variability (HRV) normalization may serve as a surrogate marker of the changes in brain function caused by repetitive transcranial magnetic stimulation (rTMS) that are associated with symptomatic improvement in depression.

Status
Recruiting
Principal Investigator
Fidel Vila-Rodriguez
Body Locations and Systems
Brain and Nerves
Age
19-65

Burden of using intermittent catheters in people with spinal cord injury

The purpose of this study is to obtain a realistic picture of the microbiological burden associated with catheter re-use, provide evidence for time spent on bladder management and provide evidence for time spent cleaning catheters for re-use.

Recruitment Poster

Status
Recruiting
Principal Investigator
Andrei Krassioukov
Body Locations and Systems
Brain and Nerves
Kidneys and Urinary System

Drug study of PRAX-944 to treat adults with essential tremor

The purpose of this study is to evaluate the effectiveness and tolerability of an oral study drug in individuals who experience upper limb essential tremor. Eligible participants will be randomly assigned to three different doses of the study drug or to a placebo.

Status
Recruiting
Principal Investigator
Silke Cresswell
Body Locations and Systems
Brain and Nerves
Age
18 and above

fMRI and Response Inhibition in Individuals with Bipolar Disorder

The purpose of this study is to look at the link between regions of brain activity and impulsivity and to look at a non-invasive intervention called repetitive transcranial magnetic stimulation (rTMS) to help reduce the risk of impulsive behaviours.

Status
Recruiting
Principal Investigator
Christian Schütz
Body Locations and Systems
Brain and Nerves
Area
Vancouver
Age
19-45

Somatotopy in Parkinson’s disease

The purpose of this study is to investigate changes in the brain in people affected by Parkinson’s disease using PET and fMRI imaging.

Status
Recruiting
Principal Investigator
Jon Stoessl
Body Locations and Systems
Brain and Nerves
Area
Vancouver
Age
50-85

PD Hypotension Study

The purpose of this study is to investigate whether Electrical Vestibular Stimulation (EVS) can lessen orthostatic hypotension in Parkinson’s disease patients. We aim to determine if individual precision-designed EVS stimulus can be optimized for improvements in hypotension.

Status
Recruiting
Principal Investigator
Martin McKeown
Body Locations and Systems
Blood, Heart and Circulation
Brain and Nerves
Area
Vancouver
Age
55-85

GEMINI 1

The purpose of this study is to assess the efficacy of two drug treatments measured by annualized adjudicated relapse rate (ARR) in participants with relapsing forms of MS.

Status
Recruiting
Principal Investigator
Virginia Devonshire
Body Locations and Systems
Brain
Multiple Sclerosis
Age
18 - 55

Asian Cohort for Alzheimer’s Disease

The purpose of this study is to investigate the impact of genetic and non-genetic risk factors for Alzheimer’s disease (AD), evaluate differential
effects of sex on AD risk, and predict diagnosis of AD using dementia risk scores derived from genetic and nongenetic risk factors.

Status
Recruiting
Principal Investigator
Ging-Yuek Robin Hsiung
Body Locations and Systems
Brain
Alzheimer's Disease
Age
60 and above

PORT Trial

The purpose of this study is to evaluate the feasibility of using repetitive transcranial magnetic stimulation (rTMS) to treat depression. 

Status
Recruiting
Principal Investigator
Fidel Vila-Rodriguez
Body Locations and Systems
Brain
Area
Vancouver
Age
18 and above

A Study of TAK-079 in People With Generalized Myasthenia Gravis

The purpose of this study is to test the safety and efficacy of TAK-079, a medicine to help people with generalized myasthenia gravis.

Status
Recruiting
Principal Investigator
Michelle M. Mezei
Body Locations and Systems
Brain and Nerves
Area
Vancouver
Age
18 and above

Perimenopause Brain Health

The purpose of this study is to is to examine the effects of 12 weeks of high intensity interval training on the cognitive health of perimenopausal woman.

Status
Recruiting
Principal Investigator
Teresa Liu-Ambrose
Body Locations and Systems
Brain
Women's Health
Area
Vancouver
Age
45-55

Magnetic Seizure Therapy for Parkinson’s Disease

The purpose of this study is to test the feasibility of Magnetic Seizure Therapy for treating depression in patients diagnosed with Parkinson's Disease.

Status
Recruiting
Principal Investigator
Fidel Vila-Rodriguez
Body Locations and Systems
Parkinson's Disease
Movement Disorders
Area
Vancouver
Age
50 and above

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