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Brain and Nerves

Recruiting

Serial Comparisons of Abdominal and Neurological MRI Scans (SCANMRI)

The purpose of this study is to compare abdominal weight gain and fat distribution to changes in brain morphology in people taking antipsychotic medications.

Status
Recruiting
Body Locations and Systems
Brain
Area
Vancouver
Age
12 and above

Canadian Fabry Disease Initiative (CFDI) Enzyme Replacement Therapy (ERT) Study

CFDI STUDY with ENZYME REPLACEMENT THERAPY (ERT)

Fabry disease is a rare, inherited, genetic condition due to a deficiency of an enzyme called alpha-galactosidase A. This enzyme deficiency causes the small blood vessels to accumulate a substance called glycolipid. Without sufficient levels of the enzyme, alpha-galactosidase A, persons with Fabry Disease develop severe neuropathic pain, kidney disease, heart disease, stroke and/or premature death; often before the age of 60.

Status
Recruiting
Principal Investigator
Sandra Sirrs
Body Locations and Systems
Brain
Area
Vancouver
Age
5-85

Coping styles and their correlation to outcomes in Parkinson's Disease

Parkinson's Disease (PD) is a progressive neurodegenerative disorder without a cure. While the search for a cure continues, there is a growing interest in psychiological approaches to manage distress in PD. The main objective of this study is to investigate various clinical outcomes in PD associated with different coping styles. Findings from this study will form the basis for projects aimed at designing interventions to foster beneficial coping styles and studies into the neural underpinnings of coping. 

Status
Recruiting
Principal Investigator
Silke Cresswell
Body Locations and Systems
Parkinson's Disease
Area
Vancouver
Age
18 and above

tDCS in Parkinson's Disease With Depression

Parkinson's disease (PD) is a progressive neurological disease that has effects on both movement and mental health. One of the most common mental health complications of PD is depression. Up to 30% of Parkinson's patients will experience depression at some point. We aim to investigate whether transcranial direct current stimulation (tDCS), a type of electrical stimulation for the brain, can improve depression in PD as well as improve motor function in PD.

Status
Recruiting
Principal Investigator
Jon Stoessl
Body Locations and Systems
Parkinson's Disease
Depression
Area
Vancouver
Age
19 and above

Repetitive Transcranial Magnetic Stimulation in the Treatment of Major Depressive Disorder

This trial will compare a novel form of rTMS, intermittent Theta Burst Stimulation to the standard conventional high frequency left sided stimulation protocol. The Left dorsolateral prefrontal cortex will be the site of stimulation in both treatment conditions. The site of stimulation will be targeted using MRI co-registration.

Status
Recruiting
Principal Investigator
Fidel Vila-Rodriguez
Body Locations and Systems
Depression
Area
Vancouver
Age
51-60

Imaging Tau Accumulation with PBB3 in Healthy Controls

Parkinson's disease results from the loss of dopamine producing brain cells; however, the mechanism that start and continue this loss are still largerly unknkown. Recent research has suggested a protein called tau may contribute to the development and progression of Parksinon's disease. Using Positron Emission Tomography (PET), a brain imaging technique, we hope to determine if and how much tau is present in healthy control subjects. This control data will then be used for comparison for data collected in patients with Parkinson's and related diseases.

Status
Recruiting
Principal Investigator
Jon Stoessl
Body Locations and Systems
Parkinson's Disease
Area
Vancouver
Age
19-85

Study of the Effect of Dosing on Clozapine Levels (PK-CLZ)

The objectives of this 15-day study are:

  • To compare steady-state trough plasma concentrations of clozapine and its metabolite norclozapine when given once daily and twice daily (at the same total daily dose)
  • To determine if frequency of clozapine administration has an effect on:
    • Symptoms of schizophrenia
    • Adverse effects of clozapine
    • Fasting blood glucose, lipids, creatinine, and urea
    • Weight and waist circumference
Status
Recruiting
Principal Investigator
Ric Procyshyn
Body Locations and Systems
Brain
Area
Vancouver
Age
19-65

Cardiovascular Health/Outcomes: Improvements Created by Exercise and Eduction in SCI (CHOICES)

This study aims to determine whether body weight-supported treadmill training (BWSTT) has beneficial effects, over and above arm-cycle ergometry training (ACET) on indicators of cardiovascular disease (CVD) risk in individuals with severe spinal cord injury (SCI).

Status
Recruiting
Principal Investigator
Andrei Krassioukov
Body Locations and Systems
Spinal Cord Injury
Area
Vancouver
Age
18-60

Closed for Recruitment

Safety and Efficacy Study of Ravulizumab in Adults With Generalized Myasthenia Gravis

The  purpose of this study is to evaluate the safety and efficacy of the drug ravulizumab for the treatment of participants with generalized myasthenia gravis.

Status
Closed for Recruitment
Principal Investigator
Michelle M. Mezei
Body Locations and Systems
Brain and Nerves
Area
Vancouver
Age
18 and above

Safety and Efficacy of NA-1 in Subjects Undergoing Endovascular Thrombectomy for Stroke (ESCAPE-NA1)

The ESCAPE-NA-1 study is designed to determine the safety and efficacy of the neuroprotectant, NA-1, in reducing global disability in subjects with major acute ischemic stroke (AIS) who are selected for endovascular revascularization.

Status
Closed for Recruitment
Principal Investigator
Thalia Field
Body Locations and Systems
Stroke
Area
Vancouver
Age
18 years and above

Study to Evaluate the Effectiveness and Safety of Ocrelizumab in Participants With Early Stage Relapsing Remitting Multiple Sclerosis (RRMS)

This is a prospective, multicenter, open-label, single-arm, phase 3b study which evaluates effectiveness and safety of ocrelizumab in participants with early stage RRMS. The study will consist of an open-label treatment period of 192 weeks and follow-up period of at least 48 weeks.

Status
Closed for Recruitment
Principal Investigator
Robert Carruthers
Body Locations and Systems
Multiple Sclerosis
Area
Vancouver
Age
18 - 55 years

Parkinson's disease and the microbiome of the gut and nose

There is a new theory that Parkinson's disease may start in the gut, but research is limited.  The purpose of this study is to better understand the association between Parkinson's disease and the bacteria and fungi living in the gut and nose.

Recruitment poster

Status
Closed for Recruitment
Principal Investigator
Silke Cresswell
Body Locations and Systems
Parkinson's Disease
Area
Vancouver
Age
40-80

Effect of MD1003 in Progressive Multiple Sclerosis (SPI2)

The purpose of this study is to demonstrate the superiority of MD1003 over placebo in the disability of patients suffering from progressive multiple sclerosis and especially those with gait impairment

Status
Closed for Recruitment
Principal Investigator
Virginia A. Devonshire
Body Locations and Systems
Multiple Sclerosis
Area
Vancouver
Age
18 - 65 years

Establishing an Imaging Biomarker for Disease Progression in Multiple Sclerosis

MS is a disabling neurological disease with a highly variable clinical course including acute disability (relapses when symptoms appear or worsen) and disease progression (steady accumulation of disability in the absence of relapses). There is currently no approved treatment for progressive MS. A principal pathology of MS is the destruction of myelin, which surrounds nerves to speed up signal conduction. We have developed a magnetic resonance imaging technique that provides quantitative measurements of myelin.

Status
Closed for Recruitment
Principal Investigator
Shannon Kolind
Body Locations and Systems
Multiple Sclerosis
Area
Vancouver
Age
18-65

Efficacy and Safety of Ofatumumab Compared to Teriflunomide in Patients With Relapsing Multiple Sclerosis (ASCLEPIOS I)

 

To compare the efficacy and safety of ofatumumab administered subcutaneously (sc) every 4 weeks versus teriflunomide administered orally once daily in patients with relapsing multiple sclerosis.

Status
Closed for Recruitment
Principal Investigator
Robert Carruthers
Body Locations and Systems
Multiple Sclerosis
Area
Vancouver
Age
18-55

Wellness Monitoring for Major Depressive Disorder

The Wellness Monitoring for Major Depressive Disorder (MDD) study is a prospective, longitudinal, observational study aimed at identifying biomarkers of relapse in MDD. Results may help refine clinical approach to relapse management, and may ultimately help MDD patients sustain wellness while on antidepressant medication.

Recruitment Poster

Status
Closed for Recruitment
Principal Investigator
Raymond Lam
Body Locations and Systems
Depression
Area
Vancouver
Age
18-60

Study to Explore the Mechanism of Action of Ocrelizumab and B-Cell Biology in Participants With Relapsing Multiple Sclerosis (RMS) or Primary Progressive Multiple Sclerosis (PPMS)

This is an exploratory biomarker study designed to be hypothesis-generating in order to better understand the mechanism of action of ocrelizumab and B-Cell biology in relapsing multiple sclerosis (RMS). 

Status
Closed for Recruitment
Principal Investigator
Robert Carruthers
Body Locations and Systems
Multiple Sclerosis
Area
Vancouver
Age
18-55

Buying Time: Improving Sleep to Promote Cognitive Function in Older Adults

The purpose of this study is to investigate whether a comprehensive group education combined with a lifestyle "activation" program that includes (a) sleep hygiene course, (b) physical activity promotion, and (c) bright light therapy, can improve both sleep quality and cognitive function among 96 community-dwelling older adults.

 
Status
Closed for Recruitment
Principal Investigator
Teresa Liu-Ambrose
Body Locations and Systems
Brain
Area
Vancouver
Age
65-85

The effect of secondary attentional tasks on smooth pursuit eye movements and reaction time in mild traumatic brain injury

This study investigates the use of eye tracking technology as a diagnostic tool for mild traumatic brain injury (mTBI) and concussion. We are looking at the effect of additional working memory (short-term memory) load on the smoothness of eye movements in both concussed and healthy populations.

Status
Closed for Recruitment
Principal Investigator
William Panenka
Body Locations and Systems
Traumatic Brain Injury
Men's and Women's Health
Area
Vancouver
Age
18-50

Bipolar Depression and the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS)

The purpose of this study is to assess the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS), a non-invasive (does not enter the body) technique in improving depressive symptoms.

Recruitment Poster

Status
Closed for Recruitment
Principal Investigator
Lakshmi Yatham
Body Locations and Systems
Bipolar Disorder
Depression
Area
Vancouver
Age
18-70

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