The purpose of this study is to evaluate the efficacy and safety of ocrelizumab ( Ocrevus®) compared with placebo in participants with primary progressive multiple sclerosis (PPMS).
The purpose of this study is examine the use of low concentration capsaicin (the active ingredient in chili peppers) cream applied for extended periods of time to help manage neuropathic pain after spinal cord injury.
The purpose of this study is to evaluate the safety and effectiveness of non-invasive electrical spinal stimulation for restoration of upper extremity function.
The purpose of this study is to determine whether a regular program of exercise, performed in a person's home or in fitness facility, can significantly reduce chronic pain in adults with spinal cord injury.
The purpose of this study is to determine ways to meet the social needs related to loneliness and isolation in seniors with dementia while examing barriers and successes surrounding the use of a robot-assisted, virtual care solution within care settings.
This project is investigating the immediate and long-term effects of non-invasive transcutaneous spinal cord stimulation (TCSCS) on bladder, bowel, and sexual function in people with SCI.
This project aims to assess the efficacy of activity-based therapy in combination with non-invasive transcutaneous spinal cord stimulation to promote the recovery of motor function, bowel function, bladder function, sexual function and quality of life in individuals with spinal cord injury.
The purpose of this study is to evaluate the use of an oral multi-strain probiotic in the treatment of anxiety in individuals with Parkinson's Disease.
The purpose of this study is to evaluate the efficacy and safety of the drug pridopidine in patients with early stage manifest Huntington Disease.
The purpose of the study is to better understand the safety of using combination antithrombotic therapy in patients with high risk transient ischemic attack (TIA) or ischemic stroke secondary to ICAD (intracranial atherosclerotic disease) for prevention of recurrent stroke.
The purpose of the study is to evaluate the long-term safety and tolerability of aducanumab in participants who had previously participated in aducanumab studies.
The purpose of this study is to develop a better understanding of the response of heat desensitized skin, resulting from prolonged low percentage capsaicin application, following an adjacent primary sensitization to the surrounding skin.
This project will explore the effect of exercise on brain energetics using functional MRI and PET imaging in people with Parkinson's disease.
The purpose of this study is to explore the experiences and impacts of social media support and in-person support on the well-being of family caregivers of individuals with spinal cord injury.
The purpose of the study is to examine the feasibility and effectiveness of a 4-week lower extremity telerehabilitation protocol with aims to improve lower extremity recovery amoung community-living stroke survivors.
The purpose of the study is to evaluate the impact of the COVID-19 pandemic on individuals with spinal cord injury (SCI) in terms of mental health and tele-rehabilitation, and to obtain suggestions from the community for improving these services during periods that require physical distancing.
This randomized controlled trial will enrol patients with acute severe brain injury who pass a spontaneous breathing trial but have decreased level of consciousness. It will directly compare (1) prompt extubation vs. (2) prompt tracheostomy vs. (3) usual care, with extubation or tracheostomy timed according to physicians' discretion. The primary outcome will be ICU free days (days spent alive and outside an ICU).
The purpose of the main study is to investigate adverse drug reactions from multiple sclerosis (MS) disease modifying drugs by understanding the genetic factors that contribute to their cause.
The sub-study investigates how the MS disease modifying drugs affect microbes in the gut and how human DNA affects the changes in the gut microbes following drug treatment. We are also interested in how gut microbes might relate to progressive MS.
This is an observational study designed to determine the relationship between quantitative advanced MRI measures and OCT with PET measurements of microglial activation and myelin health.
To determine the effects of aerobic exercise on hippocampal volumes and severity of psychotic symptoms in a population of psychosis patients compared to healthy age/gender matched volunteers. Psychosis patients often suffer from a number of cognitive difficulties, including poor memory function, poor problem-solving capacity and difficulties with attention and concentration. These problems are not well addressed by current clinical treatments.