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Brain and Nerves

Recruiting

Repetitive Transcranial Magnetic Stimulation in the Treatment of Major Depressive Disorder

This trial will compare a novel form of rTMS, intermittent Theta Burst Stimulation to the standard conventional high frequency left sided stimulation protocol. The Left dorsolateral prefrontal cortex will be the site of stimulation in both treatment conditions. The site of stimulation will be targeted using MRI co-registration.

Status
Recruiting
Principal Investigator
Fidel Vila-Rodriguez
Body Locations and Systems
Depression
Area
Vancouver
Age
51-60

Study of the Effect of Dosing on Clozapine Levels (PK-CLZ)

The objectives of this 15-day study are:

  • To compare steady-state trough plasma concentrations of clozapine and its metabolite norclozapine when given once daily and twice daily (at the same total daily dose)
  • To determine if frequency of clozapine administration has an effect on:
    • Symptoms of schizophrenia
    • Adverse effects of clozapine
    • Fasting blood glucose, lipids, creatinine, and urea
    • Weight and waist circumference
Status
Recruiting
Principal Investigator
Ric Procyshyn
Body Locations and Systems
Brain
Area
Vancouver
Age
19-65

Cardiovascular Health/Outcomes: Improvements Created by Exercise and Eduction in SCI (CHOICES)

This study aims to determine whether body weight-supported treadmill training (BWSTT) has beneficial effects, over and above arm-cycle ergometry training (ACET) on indicators of cardiovascular disease (CVD) risk in individuals with severe spinal cord injury (SCI).

Status
Recruiting
Principal Investigator
Andrei Krassioukov
Body Locations and Systems
Spinal Cord Injury
Area
Vancouver
Age
18-60

Closed for Recruitment

Verifying the clinical benefit of a drug for people with Alzheimer's disease

The purpose of this study is to verify the clinical benefit of aducanumab compared with placebo in participants with Alzheimer’s disease, including those with mild cognitive impairment due to Alzheimer’s disease or mild Alzheimer’s disease dementia.

Status
Closed for Recruitment
Principal Investigator
Ging-Yuek Robin Hsiung
Body Locations and Systems
Brain and Nerves
Age
60-85

Improving bladder dysfunction with spinal cord neuromodulation therapy

The purpose of this study is to evaluate the effectiveness and safety of a spinal cord neuromodulation (SCONE) therapy in improving symptoms of neurogenic lower urinary tract dysfunction, as compared to an inactive sham control.

Status
Closed for Recruitment
Principal Investigator
Andrei Krassioukov
Body Locations and Systems
Brain and Nerves
Kidneys and Urinary System
Age
18-75

Evaluating colchicine to prevent vascular events after hemorrhage

The purpose of this study is to determine if the use of colchicine, a drug that reduces inflammation, can lower the risk of having a stroke or heart attack from blood clots compared to placebo, and improve recovery in people with a recent brain bleed.

Status
Closed for Recruitment
Principal Investigator
Thalia Field
Body Locations and Systems
Blood, Heart and Circulation
Brain and Nerves
Age
18 and above

Testing the Brain Health PRO support program

The purpose of this study is to test an educational program called Brain Health PRO. This program is designed to teach you about dementia risk factors. It will provide best available evidence for lifestyle changes that may help lower dementia risk, including exercise, nutrition, sleep, and social and psychological health.

Status
Closed for Recruitment
Principal Investigator
Haakon Nygaard
Body Locations and Systems
Brain and Nerves
Age
60-85

Developing an adaptive fashion guide for people with spinal cord injury

The purpose of this study is to create an adaptive clothing guide (FashionABLE) with an open-source library of clothing hacks and newly developed patterns of adaptive clothing that offers diverse, appropriate and fashion-forward clothing options that meet the functional and social needs of persons with spinal cord injury.

Status
Closed for Recruitment
Principal Investigator
Andrei Krassioukov
Body Locations and Systems
Brain and Nerves
Age
19-65

Somatotopy in Parkinson’s disease

The purpose of this study is to investigate changes in the brain in people affected by Parkinson’s disease using PET and fMRI imaging.

Status
Closed for Recruitment
Principal Investigator
Jon Stoessl
Body Locations and Systems
Brain and Nerves
Area
Vancouver
Age
50-85

A Feasibility Study of Adherence to Light Therapy for Maintenance Treatment of Major Depressive Disorder

The purpose of this study is to explore the use of bright light therapy as maintenance treatment for depression to determine if it is

Status
Closed for Recruitment
Principal Investigator
Raymond Lam
Body Locations and Systems
Depression
Area
Vancouver
Age
19 - 65

Canadian Biomarker Integration Network for Depression (CAN-BIND) - Validation Study

The purpose of this study is to learn about biomarkers (biological features such as proteins, genes, and brain images that indicate the state of a disease in a person), and how they can help predict treatment outcomes in patients with clinical depression. 

Status
Closed for Recruitment
Principal Investigator
Raymond Lam
Body Locations and Systems
Depression
Area
Vancouver
Age
18-60

Safety and Efficacy Study of Ravulizumab in Adults With Generalized Myasthenia Gravis

The  purpose of this study is to evaluate the safety and efficacy of the drug ravulizumab for the treatment of participants with generalized myasthenia gravis.

Status
Closed for Recruitment
Principal Investigator
Michelle M. Mezei
Body Locations and Systems
Brain and Nerves
Area
Vancouver
Age
18 and above

Nanocrystalline Gold to Treat Remyelination Failure in Chronic Optic Neuropathy In Multiple Sclerosis (VISIONARY-MS)

The purpose of this study is to assess the efficacy and safety of CNM-Au8 as a remyelinating therapy in patients with stable relapsing-remitting multiple
sclerosis (RMS).

Status
Closed for Recruitment
Principal Investigator
Anthony Traboulsee
Body Locations and Systems
Multiple Sclerosis
Area
Vancouver
Age
18 - 55

Efficacy, Safety, and Tolerability of Valbenazine for the Treatment of Chorea Associated With Huntington Disease (KINECT-HD)

The purpose of this study is to assess the safety and tolerability of valbenazine for the treatment of chorea associated with Huntington's Disease.

Status
Closed for Recruitment
Principal Investigator
Lynn Raymond
Body Locations and Systems
Huntington's Disease
Area
Vancouver
Age
18 - 75

Examining the chronic burden of neuropsychiatric illness in COVID-19 patients

The purpose of this study is to explore certain aspects of the blood and brain to determine how a person may recover from COVID-19. In addition, this study will examine how the different aspects of COVID-19 may affect how a person thinks or feels. 

Status
Closed for Recruitment
Principal Investigator
William Panenka
Body Locations and Systems
Brain and Nerves
Immune System
Lungs and Breathing
Age
14-90

A Prospective Observational Study of Patients With Primary Mitochondrial Disease (SPIMM-300)

This is an observational study of patients with Primary Mitochondrial Disease with either signs or symptoms suggestive of myopathy. 

Status
Closed for Recruitment
Principal Investigator
Anna Lehman
Body Locations and Systems
Brain and Nerves
Area
Vancouver
Age
16-65 years

Safety and Efficacy of NA-1 in Subjects Undergoing Endovascular Thrombectomy for Stroke (ESCAPE-NA1)

The ESCAPE-NA-1 study is designed to determine the safety and efficacy of the neuroprotectant, NA-1, in reducing global disability in subjects with major acute ischemic stroke (AIS) who are selected for endovascular revascularization.

Status
Closed for Recruitment
Principal Investigator
Thalia Field
Body Locations and Systems
Stroke
Area
Vancouver
Age
18 years and above

Study to Evaluate the Effectiveness and Safety of Ocrelizumab in Participants With Early Stage Relapsing Remitting Multiple Sclerosis (RRMS)

This is a prospective, multicenter, open-label, single-arm, phase 3b study which evaluates effectiveness and safety of ocrelizumab in participants with early stage RRMS. The study will consist of an open-label treatment period of 192 weeks and follow-up period of at least 48 weeks.

Status
Closed for Recruitment
Principal Investigator
Robert Carruthers
Body Locations and Systems
Multiple Sclerosis
Area
Vancouver
Age
18 - 55 years

Parkinson's disease and the microbiome of the gut and nose

There is a new theory that Parkinson's disease may start in the gut, but research is limited.  The purpose of this study is to better understand the association between Parkinson's disease and the bacteria and fungi living in the gut and nose.

Recruitment poster

Status
Closed for Recruitment
Principal Investigator
Silke Appel-Cresswell
Body Locations and Systems
Parkinson's Disease
Area
Vancouver
Age
40-80

Effect of MD1003 in Progressive Multiple Sclerosis (SPI2)

The purpose of this study is to demonstrate the superiority of MD1003 over placebo in the disability of patients suffering from progressive multiple sclerosis and especially those with gait impairment

Status
Closed for Recruitment
Principal Investigator
Virginia Devonshire
Body Locations and Systems
Multiple Sclerosis
Area
Vancouver
Age
18 - 65 years

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