The purpose of this study is to compare abdominal weight gain and fat distribution to changes in brain morphology in people taking antipsychotic medications.
CFDI STUDY with ENZYME REPLACEMENT THERAPY (ERT)
Fabry disease is a rare, inherited, genetic condition due to a deficiency of an enzyme called alpha-galactosidase A. This enzyme deficiency causes the small blood vessels to accumulate a substance called glycolipid. Without sufficient levels of the enzyme, alpha-galactosidase A, persons with Fabry Disease develop severe neuropathic pain, kidney disease, heart disease, stroke and/or premature death; often before the age of 60.
Parkinson's Disease (PD) is a progressive neurodegenerative disorder without a cure. While the search for a cure continues, there is a growing interest in psychiological approaches to manage distress in PD. The main objective of this study is to investigate various clinical outcomes in PD associated with different coping styles. Findings from this study will form the basis for projects aimed at designing interventions to foster beneficial coping styles and studies into the neural underpinnings of coping.
This trial will compare a novel form of rTMS, intermittent Theta Burst Stimulation to the standard conventional high frequency left sided stimulation protocol. The Left dorsolateral prefrontal cortex will be the site of stimulation in both treatment conditions. The site of stimulation will be targeted using MRI co-registration.
The objectives of this 15-day study are:
This study aims to determine whether body weight-supported treadmill training (BWSTT) has beneficial effects, over and above arm-cycle ergometry training (ACET) on indicators of cardiovascular disease (CVD) risk in individuals with severe spinal cord injury (SCI).
The purpose of this study is to learn about the questions people with spinal cord injuries/disorders (SCI/D) and health care professionals have about perimenopause and menopause. This study will help determine the priority areas for research, care and education for persons with SCI/D during perimenopause and menopause. The new knowledge obtained from this study will be used in the translation efforts in perimenopause and menopause care for people with SCI/D.
The purpose of this study is to collect brain scans, blood samples, memory test scores and cerebrospinal fluid from people with Alzheimer's disease (AD), mild cognitive impairment or no memory impairment. The information collected in the study may help characterize the early stages of AD, and shape the criteria for earlier diagnosis and treatment of AD. It will also be used to discover, standardize and validate measures and biomarkers that are used in AD research. The ADNI4 study is a continuation of the ADNI3 study and will also open to enroll new participants.
The purpose of this study is to verify the clinical benefit of aducanumab compared with placebo in participants with Alzheimer’s disease, including those with mild cognitive impairment due to Alzheimer’s disease or mild Alzheimer’s disease dementia.
The purpose of this study is to evaluate the effectiveness and safety of a spinal cord neuromodulation (SCONE) therapy in improving symptoms of neurogenic lower urinary tract dysfunction, as compared to an inactive sham control.
The purpose of this study is to determine if the use of colchicine, a drug that reduces inflammation, can lower the risk of having a stroke or heart attack from blood clots compared to placebo, and improve recovery in people with a recent brain bleed.
The purpose of this study is to test an educational program called Brain Health PRO. This program is designed to teach you about dementia risk factors. It will provide best available evidence for lifestyle changes that may help lower dementia risk, including exercise, nutrition, sleep, and social and psychological health.
The purpose of this study is to create an adaptive clothing guide (FashionABLE) with an open-source library of clothing hacks and newly developed patterns of adaptive clothing that offers diverse, appropriate and fashion-forward clothing options that meet the functional and social needs of persons with spinal cord injury.
The purpose of this study is to investigate changes in the brain in people affected by Parkinson’s disease using PET and fMRI imaging.
The purpose of this study is to evaluate the feasibility of using repetitive transcranial magnetic stimulation (rTMS) to treat depression.
The purpose of this study is to test the safety and efficacy of TAK-079, a medicine to help people with generalized myasthenia gravis.
The purpose of this study is to is to examine the effects of 12 weeks of high-intensity interval training on the cognitive health of perimenopausal women.
The purpose of this study is to explore the use of bright light therapy as maintenance treatment for depression to determine if it is
The purpose of this study is to learn about biomarkers (biological features such as proteins, genes, and brain images that indicate the state of a disease in a person), and how they can help predict treatment outcomes in patients with clinical depression.
The purpose of this study is to evaluate the safety and efficacy of the drug ravulizumab for the treatment of participants with generalized myasthenia gravis.