GEMINI 1
The purpose of this study is to assess the efficacy of two drug treatments measured by annualized adjudicated relapse rate (ARR) in participants with relapsing forms of MS.
Status
Recruiting
Recruiting
Asian Cohort for Alzheimer’s Disease
The purpose of this study is to investigate the impact of genetic and non-genetic risk factors for Alzheimer’s disease (AD), evaluate differential
effects of sex on AD risk, and predict diagnosis of AD using dementia risk scores derived from genetic and nongenetic risk factors.
Status
Recruiting
PORT Trial
The purpose of this study is to evaluate the feasibility of using repetitive transcranial magnetic stimulation (rTMS) to treat depression.
Status
Recruiting
Perimenopause Brain Health
The purpose of this study is to is to examine the effects of 12 weeks of high intensity interval training on the cognitive health of perimenopausal woman.
Status
Recruiting
Magnetic Seizure Therapy for Parkinson’s Disease
The purpose of this study is to test the feasibility of Magnetic Seizure Therapy for treating depression in patients diagnosed with Parkinson's Disease.
Status
Recruiting
A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (O'HAND)
The purpose of this study is to evaluate the efficacy and safety of ocrelizumab ( Ocrevus®) compared with placebo in participants with primary progressive multiple sclerosis (PPMS).
Status
Recruiting
A Feasibility Study of Adherence to Light Therapy for Maintenance Treatment of Major Depressive Disorder
The purpose of this study is to explore the use of bright light therapy as maintenance treatment for depression to determine if it is
Status
Recruiting
Co-Investigation of Robotic-Assisted Virtual Care for Older People with Dementia - Phase 1
The purpose of this study is to determine ways to meet the social needs related to loneliness and isolation in seniors with dementia while examing barriers and successes surrounding the use of a robot-assisted, virtual care solution within care settings.
Status
Recruiting
Treating Anxiety in Parkinson's Disease With a Multi-Strain Probiotic (TAP)
The purpose of this study is to evaluate the use of an oral multi-strain probiotic in the treatment of anxiety in individuals with Parkinson's Disease.
Status
Recruiting
PRidopidine's Outcome On Function in Huntington Disease (PROOF- HD)
The purpose of this study is to evaluate the efficacy and safety of the drug pridopidine in patients with early stage manifest Huntington Disease.
Status
Recruiting
Canadian Biomarker Integration Network for Depression (CAN-BIND) - Validation Study
The purpose of this study is to learn about biomarkers (biological features such as proteins, genes, and brain images that indicate the state of a disease in a person), and how they can help predict treatment outcomes in patients with clinical depression.
Status
Recruiting
Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in Intracranial Atherosclerotic Disease
The purpose of the study is to better understand the safety of using combination antithrombotic therapy in patients with high risk transient ischemic attack (TIA) or ischemic stroke secondary to ICAD (intracranial atherosclerotic disease) for prevention of recurrent stroke.
Status
Recruiting
A Study to Evaluate Safety and Tolerability of Aducanumab in Participants With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205
The purpose of the study is to evaluate the long-term safety and tolerability of aducanumab in participants who had previously participated in aducanumab studies.
Status
Recruiting
Nanocrystalline Gold to Treat Remyelination Failure in Chronic Optic Neuropathy In Multiple Sclerosis (VISIONARY-MS)
The purpose of this study is to assess the efficacy and safety of CNM-Au8 as a remyelinating therapy in patients with stable relapsing-remitting multiple
sclerosis (RMS).
Status
Recruiting
Longitudinal Study of the Clinical Epidemiology of Parkinson's Disease and Parkinson Plus Syndromes
The purpose of this study is to establish a local registry comprised of patients with Parkinson's Disease and Parkinson Plus Syndromes to mainstream research efforts and find more efficient ways to treat Parkinson's Disease.
Status
Recruiting
The Effect of Exercise on Brain Energetics in Parkinson’s disease
This project will explore the effect of exercise on brain energetics using functional MRI and PET imaging in people with Parkinson's disease.
Status
Recruiting
Efficacy, Safety, and Tolerability of Valbenazine for the Treatment of Chorea Associated With Huntington Disease (KINECT-HD)
The purpose of this study is to assess the safety and tolerability of valbenazine for the treatment of chorea associated with Huntington's Disease.
Status
Recruiting
Telerehabilitation With Aims to Improve Lower Extremity Recovery Post-Stroke (TRAIL)
The purpose of the study is to examine the feasibility and effectiveness of a 4-week lower extremity telerehabilitation protocol with aims to improve lower extremity recovery amoung community-living stroke survivors.
Status
Recruiting
COVID-19 NeuroOutcomes (CONOS)
This study is exploring certain aspects of the blood and brain to determine how a person may recover from COVID-19. In addition, this study will examine how the different aspects of COVID-19 may affect how a person thinks or feels.
Status
Recruiting
The NEUROlogically-impaired Extubation Timing Trial (NEURO-ETT)
This randomized controlled trial will enrol patients with acute severe brain injury who pass a spontaneous breathing trial but have decreased level of consciousness. It will directly compare (1) prompt extubation vs. (2) prompt tracheostomy vs. (3) usual care, with extubation or tracheostomy timed according to physicians' discretion. The primary outcome will be ICU free days (days spent alive and outside an ICU).
Status
Recruiting