The purpose of this study is to evaluate the feasibility of using repetitive transcranial magnetic stimulation (rTMS) to treat depression.
The purpose of this study is to is to examine the effects of 12 weeks of high intensity interval training on the cognitive health of perimenopausal woman.
The purpose of this study is to test the feasibility of Magnetic Seizure Therapy for treating depression in patients diagnosed with Parkinson's Disease.
A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (O'HAND)
The purpose of this study is to evaluate the efficacy and safety of ocrelizumab ( Ocrevus®) compared with placebo in participants with primary progressive multiple sclerosis (PPMS).
A Feasibility Study of Adherence to Light Therapy for Maintenance Treatment of Major Depressive Disorder
The purpose of this study is to explore the use of bright light therapy as maintenance treatment for depression to determine if it is
The bWell Cognitive Care Platform to improve workplace functioning: Individuals with lived experience user interviews
The purpose of this study is to gather qualitative data from patients with depression who report functional deficits that interfere with their employment.
The purpose of this study is to determine ways to meet the social needs related to loneliness and isolation in seniors with dementia while examing barriers and successes surrounding the use of a robot-assisted, virtual care solution within care settings.
The purpose of this study is to evaluate the use of an oral multi-strain probiotic in the treatment of anxiety in individuals with Parkinson's Disease.
The purpose of this study is to evaluate the efficacy and safety of the drug pridopidine in patients with early stage manifest Huntington Disease.
The purpose of this study is to learn about biomarkers (biological features such as proteins, genes, and brain images that indicate the state of a disease in a person), and how they can help predict treatment outcomes in patients with clinical depression.
Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in Intracranial Atherosclerotic Disease
The purpose of the study is to better understand the safety of using combination antithrombotic therapy in patients with high risk transient ischemic attack (TIA) or ischemic stroke secondary to ICAD (intracranial atherosclerotic disease) for prevention of recurrent stroke.
A Study to Evaluate Safety and Tolerability of Aducanumab in Participants With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205
The purpose of the study is to evaluate the long-term safety and tolerability of aducanumab in participants who had previously participated in aducanumab studies.
Nanocrystalline Gold to Treat Remyelination Failure in Chronic Optic Neuropathy In Multiple Sclerosis (VISIONARY-MS)
The purpose of this study is to assess the efficacy and safety of CNM-Au8 as a remyelinating therapy in patients with stable relapsing-remitting multiple
The purpose of this study is to establish a local registry comprised of patients with Parkinson's Disease and Parkinson Plus Syndromes to mainstream research efforts and find more efficient ways to treat Parkinson's Disease.
This project will explore the effect of exercise on brain energetics using functional MRI and PET imaging in people with Parkinson's disease.
Efficacy, Safety, and Tolerability of Valbenazine for the Treatment of Chorea Associated With Huntington Disease (KINECT-HD)
The purpose of this study is to assess the safety and tolerability of valbenazine for the treatment of chorea associated with Huntington's Disease.
The purpose of the study is to examine the feasibility and effectiveness of a 4-week lower extremity telerehabilitation protocol with aims to improve lower extremity recovery amoung community-living stroke survivors.
This study is exploring certain aspects of the blood and brain to determine how a person may recover from COVID-19. In addition, this study will examine how the different aspects of COVID-19 may affect how a person thinks or feels.
MS is a disabling neurological disease with a highly variable clinical course including acute disability (relapses when symptoms appear or worsen) and disease progression (steady accumulation of disability in the absence of relapses). There is currently no approved treatment for progressive MS. A principal pathology of MS is the destruction of myelin, which surrounds nerves to speed up signal conduction. We have developed a magnetic resonance imaging technique that provides quantitative measurements of myelin.
This randomized controlled trial will enrol patients with acute severe brain injury who pass a spontaneous breathing trial but have decreased level of consciousness. It will directly compare (1) prompt extubation vs. (2) prompt tracheostomy vs. (3) usual care, with extubation or tracheostomy timed according to physicians' discretion. The primary outcome will be ICU free days (days spent alive and outside an ICU).