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Brain

Recruiting

GEMINI 1

The purpose of this study is to assess the efficacy of two drug treatments measured by annualized adjudicated relapse rate (ARR) in participants with relapsing forms of MS.

Status
Recruiting
Principal Investigator
Virginia A. Devonshire
Body Locations and Systems
Brain
Multiple Sclerosis
Age
18 - 55

Asian Cohort for Alzheimer’s Disease

The purpose of this study is to investigate the impact of genetic and non-genetic risk factors for Alzheimer’s disease (AD), evaluate differential
effects of sex on AD risk, and predict diagnosis of AD using dementia risk scores derived from genetic and nongenetic risk factors.

Status
Recruiting
Principal Investigator
Ging-Yuek Robin Hsiung
Body Locations and Systems
Brain
Alzheimer's Disease
Age
60 and above

PORT Trial

The purpose of this study is to evaluate the feasibility of using repetitive transcranial magnetic stimulation (rTMS) to treat depression. 

Status
Recruiting
Principal Investigator
Fidel Vila-Rodriguez
Body Locations and Systems
Brain
Area
Vancouver
Age
18 and above

Perimenopause Brain Health

The purpose of this study is to is to examine the effects of 12 weeks of high intensity interval training on the cognitive health of perimenopausal woman.

Status
Recruiting
Principal Investigator
Teresa Liu-Ambrose
Body Locations and Systems
Brain
Women's Health
Area
Vancouver
Age
45-55

Magnetic Seizure Therapy for Parkinson’s Disease

The purpose of this study is to test the feasibility of Magnetic Seizure Therapy for treating depression in patients diagnosed with Parkinson's Disease.

Status
Recruiting
Principal Investigator
Fidel Vila-Rodriguez
Body Locations and Systems
Parkinson's Disease
Movement Disorders
Area
Vancouver
Age
50 and above

A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (O'HAND)

The purpose of this study is to evaluate the efficacy and safety of ocrelizumab ( Ocrevus®) compared with placebo in participants with primary progressive multiple sclerosis (PPMS).

Status
Recruiting
Principal Investigator
Alice Schabas
Body Locations and Systems
Multiple Sclerosis
Area
Vancouver
Age
18 - 65

A Feasibility Study of Adherence to Light Therapy for Maintenance Treatment of Major Depressive Disorder

The purpose of this study is to explore the use of bright light therapy as maintenance treatment for depression to determine if it is

Status
Recruiting
Principal Investigator
Raymond Lam
Body Locations and Systems
Depression
Area
Vancouver
Age
19 - 65

Co-Investigation of Robotic-Assisted Virtual Care for Older People with Dementia - Phase 1

The purpose of this study is to determine ways to meet the social needs related to loneliness and isolation in seniors with dementia while examing barriers and successes surrounding the use of a robot-assisted, virtual care solution within care settings. 

Status
Recruiting
Principal Investigator
Lillian Hung
Body Locations and Systems
Dementia
Area
Vancouver
Age
18 and above

Treating Anxiety in Parkinson's Disease With a Multi-Strain Probiotic (TAP)

The purpose of this study is to evaluate the use of an oral multi-strain probiotic in the treatment of anxiety in individuals with Parkinson's Disease. 

Status
Recruiting
Principal Investigator
Silke Cresswell
Body Locations and Systems
Parkinson's Disease
Area
Vancouver
Age
40 - 80

PRidopidine's Outcome On Function in Huntington Disease (PROOF- HD)

The purpose of this study is to evaluate the efficacy and safety of the drug pridopidine in patients with early stage manifest Huntington Disease.

Status
Recruiting
Principal Investigator
Blair Leavitt
Body Locations and Systems
Huntington's Disease
Area
Vancouver
Age
18 and above

Canadian Biomarker Integration Network for Depression (CAN-BIND) - Validation Study

The purpose of this study is to learn about biomarkers (biological features such as proteins, genes, and brain images that indicate the state of a disease in a person), and how they can help predict treatment outcomes in patients with clinical depression. 

Status
Recruiting
Principal Investigator
Raymond Lam
Body Locations and Systems
Depression
Area
Vancouver
Age
18-60

Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in Intracranial Atherosclerotic Disease

The purpose of the study is to better understand the safety of using combination antithrombotic therapy in patients with high risk transient ischemic attack (TIA) or ischemic stroke secondary to ICAD (intracranial atherosclerotic disease) for prevention of recurrent stroke.

Status
Recruiting
Principal Investigator
Samuel Yip
Body Locations and Systems
Stroke
Area
Vancouver
Age
40 and above

A Study to Evaluate Safety and Tolerability of Aducanumab in Participants With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205

The purpose of the study is to evaluate the long-term safety and tolerability of aducanumab  in participants who had previously participated in aducanumab studies.

Status
Recruiting
Principal Investigator
Ging-Yuek Robin Hsiung
Body Locations and Systems
Alzheimer's Disease
Area
Vancouver
Age
18 and above

Nanocrystalline Gold to Treat Remyelination Failure in Chronic Optic Neuropathy In Multiple Sclerosis (VISIONARY-MS)

The purpose of this study is to assess the efficacy and safety of CNM-Au8 as a remyelinating therapy in patients with stable relapsing-remitting multiple
sclerosis (RMS).

Status
Recruiting
Principal Investigator
Anthony Traboulsee
Body Locations and Systems
Multiple Sclerosis
Area
Vancouver
Age
18 - 55

The Effect of Exercise on Brain Energetics in Parkinson’s disease

This project will explore the effect of exercise on brain energetics using functional MRI and PET imaging in people with Parkinson's disease.

Status
Recruiting
Principal Investigator
Vesna Sossi
Body Locations and Systems
Parkinson's Disease
Area
Vancouver
Age
40-80

Efficacy, Safety, and Tolerability of Valbenazine for the Treatment of Chorea Associated With Huntington Disease (KINECT-HD)

The purpose of this study is to assess the safety and tolerability of valbenazine for the treatment of chorea associated with Huntington's Disease.

Status
Recruiting
Principal Investigator
Lynn Raymond
Body Locations and Systems
Huntington's Disease
Area
Vancouver
Age
18 - 75

Telerehabilitation With Aims to Improve Lower Extremity Recovery Post-Stroke (TRAIL)

The purpose of the study is to examine the feasibility and effectiveness of a 4-week lower extremity telerehabilitation protocol with aims to improve lower extremity recovery amoung community-living stroke survivors. 

Status
Recruiting
Principal Investigator
Brodie Sakakibara
Body Locations and Systems
Stroke
Area
Vancouver
Age
19 and above

The NEUROlogically-impaired Extubation Timing Trial (NEURO-ETT)

This randomized controlled trial will enrol patients with acute severe brain injury who pass a spontaneous breathing trial but have decreased level of consciousness. It will directly compare (1) prompt extubation vs. (2) prompt tracheostomy vs. (3) usual care, with extubation or tracheostomy timed according to physicians' discretion. The primary outcome will be ICU free days (days spent alive and outside an ICU).

Status
Recruiting
Principal Investigator
Donald Griesdale
Body Locations and Systems
Brain
Lungs and Breathing
Area
Vancouver
Age
16 and above

Multiple Sclerosis, Genes, Microbes, and Medication

The purpose of the main study is to investigate adverse drug reactions from multiple sclerosis (MS) disease modifying drugs by understanding the genetic factors that contribute to their cause. 

The sub-study investigates how the MS disease modifying drugs affect microbes in the gut and how human DNA affects the changes in the gut microbes following drug treatment. We are also interested in how gut microbes might relate to progressive MS.

recruitment poster

Status
Recruiting
Principal Investigator
Helen Tremlett
Body Locations and Systems
Multiple Sclerosis
Immune System
Area
Vancouver
Age
18 and above

Correlation Between PET and Advanced MRI in Multiple Sclerosis

This is an observational study designed to determine the relationship between quantitative advanced MRI measures and OCT with PET measurements of microglial activation and myelin health. 

Status
Recruiting
Principal Investigator
Robert Carruthers
Body Locations and Systems
Multiple Sclerosis
Area
Vancouver
Age
18-60

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