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  2. Participate in Research
  3. Utilizing machine learning to optimize Parkinson's disease treatment
Research Study

An Individualized, Machine-Learning Approach for Prediction of Medication “Off” Episodes in Parkinson’s Disease (PD Sweat OFF)

Principal Investigator
Martin McKeown

Overview

Body Locations and Systems
Brain and Nerves
Parkinson's Disease
Status
Recruiting
Start/End Dates
Jan 1, 2024 Oct 31, 2025
Locations
UBC Hospital
Name/Title
Gabriella Guerra, Research Assistant
Phone
604-822-4723
Email Address
gabriella.guerra@ubc.ca
Purpose of Study

The purpose of this study is to develop a means, via a wearable sensor, to detect the subtle physiological changes that may occur before wearing off (WO) of a Parkinson's disease treatment called levodopa become consciously felt to allow for medication to be taken and absorbed in time to prevent the WO from occurring.

Participants will be able to take their medications as usual. The study involves one visit, during which participants will be taught how to wear the wrist sensor and how to navigate a questionnaire mobile application. They will be asked to continue to wear the wrist sensor for the next 72 hours and fill out a questionnaire about their symptoms every hour, excluding sleep.

Eligibility

You may be eligible to participate in this study if you are between 18 to 85 years of age with a confirmed diagnosis of idiopathic Parkinson's disease, have experienced at least two to three WO episodes per day in the past month, and do not have a history of neurological disorders (including vestibular dysfunction), neurosurgical procedures (e.g. deep brain stimulation), head surgery, depression or dementia. Individuals should be able to effectively use smartphones and should not participate if they are under levodopa/carbidopa-intestinal-gel treatment or have health conditions that make them sensitive to small electrical signals.

Disclaimer

Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers and email addresses are provided for obtaining additional information on specific research studies only. If you have specific questions which require clinical expertise, please call your primary care physician.

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