Recruiting

Exploring strategies to identify and reduce the risk of uterine cancer

The purpose of this study is to investigate risk factors, screening tools and intervention methods that could help provide early diagnosis or prevention of uterine cancer. The study will evaluate how or if these screening and intervention methods are understood, accepted and completed by postmenopausal participants. The ultimate goal is to identify people at high risk for developing endometrial (uterine) cancer through various screening techniques and then tailor an approach to reduce risk through a program of lifestyle interventions.

Status
Recruiting

Universal Screening for Lynch Syndrome in Women With Endometrial and Non-Serous Ovarian Cancer (LS2)

This study will maximize identification of women with Lynch Syndrome using an enhanced screening strategy to identify those at risk. These women will be referred to genetic counselling for testing and those found to have Lynch Syndrome will be asked to invite first degree relatives to participate and undergo genetic testing for Lynch Syndrome.

Status
Recruiting

Closed for Recruitment

Return to Everyday Activities in the Community and Home (REACH) - 8 Week Active Living and Walking Program

The purpose of this study isto increase physical activity, reduce sitting time, and increase strength and balance in middle-aged and older adults. The REACH program will help particpants change habits and embed light acitivites througout regular daily routines.

This study takes place twice a week over 8 weeks. Particpants will be asked to complete questionaires, physical performance measures and two to three interviews.

Status
Closed for Recruitment

The Study of Newcomer Women and Developmental Toxicants (The SEED Study)

 The purpose of this study is to investigate exposures to heavy metal exposures and other environmental chemicals among newcomer women of reproductive age (19-45 years) from India, China, Hong Kong, and Taiwan living in the Greater Vancouver area.  This study will help us determine if current levels of toxicants may be a public health concern.  The results of this study will help us to learn how to reduce future exposures. 

Status
Closed for Recruitment

A Physical Activity Intervention for Female Shift Workers (SWPA)

This project will assess the feasibility of a 12-week physical activity program developed specifically for females exposed to a known occupational carcinogen - shiftwork. Physical activity has been shown to decrease cancer risk, but the investigators research has found that female shift workers face unique barriers to participating in physical activity.

Status
Closed for Recruitment

A Study of Trastuzumab Emtansine (Kadcyla) Plus Pertuzumab (Perjeta) Following Anthracyclines in Comparison With Trastuzumab (Herceptin) Plus Pertuzumab and a Taxane Following Anthracyclines as Adjuvant Therapy in Participants With Primary Breast Cancer

This two-arm, randomized, open-label, multicenter study will evaluate the efficacy and safety of Kadcyla (trastuzumab emtansine, also known as T-DM1) in combination with Perjeta (pertuzumab) versus Herceptin (trastuzumab) in combination with Perjeta and a taxane as adjuvant therapy in patients with HER2-positive primary invasive breast cancer.

Status
Closed for Recruitment

Stress Hormones, Mood and Women's Sexual Desire (MODEST)

Women with Hypoactive sexual desire disorder (HSDD) have all measures of testosterone activity comparable to controls but lower levels of dehydroepiandrosterone (DHEA). Although DHEA is a precursor of testosterone it has other actions including involvement in the stress system. It is also linked to mood. This study focuses on measures of childhood stress, current mood and salivary and nail stress hormones, in women with and without HSDD.

Status
Closed for Recruitment

Oral Micronized Progesterone for Perimenopausal Vasomotor Symptoms

The purpose of this study is to test whether an oral micronized progesterone reduces the score, number and severity of hot flushes and night sweats in perimenopausal women. Oral micronized progesterone is molecularly identical to human progesterone, a steroid hormone. It is sold by prescription for use to prevent endometrial cancer in women taking estrogen in menopause. This research study will test whether progesterone reduces perimenopausal hot flushes and night sweats. It will also test whether progesterone improves sleep disturbances and anxiety.

Status
Closed for Recruitment
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