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  3. Kidneys and Urinary System

Kidneys and Urinary System

Recruiting

Burden of using intermittent catheters in people with spinal cord injury

The purpose of this study is to obtain a realistic picture of the microbiological burden associated with catheter re-use, provide evidence for time spent on bladder management and provide evidence for time spent cleaning catheters for re-use.

Recruitment Poster

Status
Recruiting
Principal Investigator
Andrei Krassioukov
Body Locations and Systems
Brain and Nerves
Kidneys and Urinary System

Dysport 222

The purpose of this study is to provide confirmatory evidence of the safety and efficacy of two Dysport® (AbobotulinumtoxinA) doses (600 units [U] and 800 U), compared to placebo in reducing urinary incontinence (UI) in adult subjects treated for neurogenic detrusor overactivity (NDO) due to spinal cord injury (SCI) or multiple sclerosis (MS).

Status
Recruiting
Principal Investigator
Lynn Stothers
Body Locations and Systems
Urinary Incontinence
Multiple Sclerosis
Spinal Cord Injury
Area
Vancouver
Age
18-80

QPI-1002 for Prevention of Delayed Graft Function in Recipients of an Older Donor Kidney Transplant (ReGIFT)

The purpose of this trial is to evaluate the reduction in incidence and severity of delayed graft function with kidney allografts from donors >45 years after brain death (DBD).

Status
Recruiting
Principal Investigator
Jagbir Gill
Body Locations and Systems
Kidney Transplantation
Area
Vancouver
Age
18 and above

Canadian-Australasian Randomized Trial of Screening Kidney Transplant Candidates for Coronary Artery Disease (CARSK)

Patients on the waiting list for kidney transplantation are at risk for coronary artery disease (CAD).  The optimal strategy to monitor and maintain the cardiac fitness of these patients is unknown. Currently patients without any symptoms of CAD undergo annual testing to determine if they have disease. This study will determine if screening is necessary.

Status
Recruiting
Principal Investigator
Jagbir Gill
Body Locations and Systems
Kidney Transplantation
Coronary Artery Disease
Area
Vancouver
Age
18 and above

A Study of Vonapanitase (PRT-201) Administered Immediately After Radiocephalic Arteriovenous Fistula(AVF) Creation in Patients With Chronic Kidney Disease (CKD) (PATENCY-2)

This research study is designed to assess the safety and effectiveness of an experimental drug called vonapanitase (PRT-201) in patients who have chronic kidney disease and who are undergoing surgery to create a new access point to their bloodstream for hemodialysis. Vonapanitase is a protein that has been shown in previous research studies to help keep vessels patent when applied to the outside surface of the blood vessels (arteries and veins) in patients who undergo surgery to create an arteriovenous fistula (AVF).

Status
Recruiting
Principal Investigator
Jerry Chen
Body Locations and Systems
Kidney Disease
Area
Vancouver
Age
18-100

Once Daily Dosing to Improve Medication Adherence and Patient Satisfaction in Kidney Transplant Recipients (OnceDaily)

Patient failure to take medications as prescribed (medication non-adherence) is now identified as an important cause of kidney transplant failure. The availability of new drugs that are taken once daily may improve patient adherence compared to older drugs that had to be taken twice per day. In this study, patients will be converted to a medication schedule where all medications are taken once daily with the goal of improving patient adherence and satisfaction.

Status
Recruiting
Principal Investigator
John Gill
Body Locations and Systems
Kidney Transplantation
Area
Vancouver
Age
18 and above

Global, Multicentre, Non Interventional Advagraf Conversion Registry in Kidney Transplant Patients (CHORUS)

A study to evaluate changes over time in renal function from baseline (time of conversion) up until five years post conversion in kidney transplant patients converted from tacrolimus twice daily (BD) formulations to a once daily formulation as Advagraf.

Status
Recruiting
Principal Investigator
John Gill
Body Locations and Systems
Kidney Transplantation
Area
Vancouver
Age
18 and above

Calcium Supplements Strategy for Kidney Stones Prevention in Crohn's Patients

Hospitalization for kidney stones in the Inflammatory Bowel Disease (IBD) population is common, particularly among Crohn's patients who had a small bowel resection. This patient population experiences a lifetime occurrence of kidney stone formation as high as 25% accompanied with a high rate of recurrence (the typical rate of stone formation is ~10% in the non IBD population). Giving oral calcium is used to bind oxalate in the intestine in an attempt to reduce the amount of oxalate that is absorbed into the body and to reduce urinary oxalate levels.

Status
Recruiting
Principal Investigator
Ben Chew
Body Locations and Systems
Kidney Stones
Crohn's Disease
Area
Vancouver
Age
19 and above

Struvite Antibiotic Study

The aim of this research is to determine an effective antibiotic regimen following definitive surgical therapy of kidney stones caused by bacterial infection (struvite stones).

Status
Recruiting
Principal Investigator
Ben Chew
Body Locations and Systems
Kidney Stones
Area
Vancouver
Age
19 and above

A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL])

Percutaneous nephrolithotomy (PCNL) is a surgical procedure that is standard of care for the removal of large kidney stones. PCNL involves removal of the stone(s) from the kidney through a temporary tract that is percutaneously placed through the patient's back during surgery. There is a significant risk of urinary tract infection after PCNL but wide clinical variation in use of prophylactic antibiotics in the days leading up to surgery.

Status
Recruiting
Principal Investigator
Ben Chew
Body Locations and Systems
Kidney Stones
Urinary Tract Infections
Area
Vancouver
Age
18 and above

Urine and Stool Analysis in Kidney Stone Disease

The purpose of this study is to add to the investigators' quest to understanding stone disease, by evaluating the metabolites excretion in urine and its relation to microflora present in the stool.

Status
Recruiting
Principal Investigator
Ben Chew
Body Locations and Systems
Kidney Stones
Area
Vancouver
Age
19-90

A Pilot Study Comparing the Use of Low-target Versus Conventional Target Advagraf (Astellas)

While the incidence of acute rejection and early graft loss have improved dramatically with the advent of newer immunosuppressant medications, improvements in long-term patient and allograft survival after kidney transplantation have not been achieved. The specific drug combination that provides the best outcomes with the least amount of side effects is not known. Each kidney transplant center uses the combination of drugs that they believe is optimal.

Status
Recruiting
Principal Investigator
Jagbir Gill
Body Locations and Systems
Kidney Transplantation
Area
Vancouver
Age
19 and above

Closed for Recruitment

Evaluation of the Effects of Canagliflozin on Renal and Cardiovascular Outcomes in Participants With Diabetic Nephropathy (CREDENCE)

The goal of this study is to assess whether canagliflozin has a renal and vascular protective effect in reducing the progression of renal impairment relative to placebo in participants with type 2 diabetes mellitus (T2DM), Stage 2 or 3 chronic kidney disease (CKD) and macroalbuminuria, who are receiving standard of care including a maximum tolerated labeled daily dose of an angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB).

Status
Closed for Recruitment
Principal Investigator
Nadia Zalunardo
Body Locations and Systems
Diabetic Kidney Problems
Diabetes - Type 2
Area
Vancouver
Age
30 and above

S1011 Standard or Extended Pelvic Lymphadenectomy in Treating Patients Undergoing Surgery for Invasive Bladder Cancer

RATIONALE: Lymphadenectomy may remove tumor cells that have spread to nearby lymph nodes in patients with invasive bladder cancer. It is not yet known whether extended pelvic lymphadenectomy is more effective than standard pelvic lymphadenectomy during surgery.

PURPOSE: This randomized phase II trial is studying standard pelvic lymphadenectomy to see how well it works compared to extended pelvic lymphadenectomy in treating patients undergoing surgery for invasive bladder cancer.

Status
Closed for Recruitment
Principal Investigator
Peter Black
Body Locations and Systems
Cancer
Area
Vancouver
Age
18-120

"Dusting" Versus "Basketing" - Treatment Of Intrarenal Stones

The purpose of this study is to evaluate outcomes of an established procedure for treatment of kidney stones that are present within the inner aspect of the kidney. This procedure is called flexible ureteroscopy, which involves placing a small camera through the urethra while anesthetized (asleep), up the ureter (the tube connecting kidney and bladder) and into the kidney to the kidney stone. Then, the stone is broken into tiny fragments using a small laser called a Holmium laser.

Status
Closed for Recruitment
Principal Investigator
Ben Chew
Body Locations and Systems
Kidney Stones
Area
Vancouver
Age
18 and above

Buttonhole Versus Step Ladder Cannulation in High Dose Hemodialysis

The purpose of the pilot study is to determine: 1) Will patients agree to be randomized to two different methods of putting needles in their arteriovenous fistula and, 2) if we can adequately coordinate all of the sites to get useful multicentre trial data

Status
Closed for Recruitment
Principal Investigator
Michael Copland
Body Locations and Systems
Dialysis
Kidney Failure
Area
Vancouver
Age
18-90

Kidney Transplant Failure

Primary Hypotheses:

Status
Closed for Recruitment
Body Locations and Systems
Kidney Transplantation
Dialysis
Kidney Failure
Area
Vancouver
Age
18 and above
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