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  3. Kidneys and Urinary System

Kidneys and Urinary System

Recruiting

Testing non-invasive spinal cord stimulation for early spinal cord injury

The purpose of this study is to investigate the safety and effectiveness of non-invasive transcutaneous spinal cord stimulation (TSCS) in conjunction with conventional rehabilitation in helping with the recovery of bladder function in persons with spinal cord injury (SCI). The study team will assess immediate TSCS efficacy when the stimulation is turned on, as well as the persisting effects of TSCS (e.g. any changes in function) that remain after the stimulation is turned off and after several weeks of regular stimulation.

Status
Recruiting
Principal Investigator
Andrei Krassioukov
Body Locations and Systems
Blood, Heart and Circulation
Brain and Nerves
Spinal Cord Injury
Kidneys and Urinary System
Bladder
Sexual Health
Age
19-65

Understanding the experiences of relocated transplant patients

The purpose of this study is to understand and document the experiences of patients who live at least 60 minutes outside of the Lower Mainland and who are traveling to Vancouver for a solid organ transplant. The research team aims to document the psychological, social, emotional and cultural impact for patients leaving their communities to access care in Vancouver. The study will also capture the associated out-of-pocket costs that these transplant patients incur before, during and after the transplant operation.

Status
Recruiting
Principal Investigator
Jude Kornelsen
Body Locations and Systems
Blood, Heart and Circulation
Digestive System
Kidneys and Urinary System
Lungs and Breathing

Collecting data for the Pacific Parkinson’s Research Centre Biobank

The purpose of this study is to collect biospecimens (fecal, urine, blood) and clinical data to serve as a resource for future research on Parkinson’s disease and other movement disorders. The careful collection, storage and retrieval of biospecimens and medical information for research projects are critical for improving understanding of healthy development and disease mechanisms and the subsequent development of effective treatments. Biospecimens from this biobank will be made available for ethically-approved studies.

Status
Recruiting
Principal Investigator
Silke Appel-Cresswell
Body Locations and Systems
Blood, Heart and Circulation
Brain and Nerves
Parkinson's Disease
Digestive System
Immune System
Kidneys and Urinary System
Mouth and Teeth
Age
19 and above

Preventing skin cancer with nicotinamide in transplant patients

The purpose of this study is to determine whether an oral vitamin called nicotinamide can help prevent skin cancer in 396 high-risk kidney, liver, heart and lung transplant recipients. Participants will be involved in the study for four years and will visit the study doctor or clinical research staff every 17 weeks. Participants will receive nicotinamide or a placebo, taken orally for the entire follow-up period, which will last up to 208 weeks.

Status
Recruiting
Principal Investigator
Sunil Kalia
Body Locations and Systems
Kidneys and Urinary System
Skin, Hair and Nails
Age
18 and above

Investigating non-invasive spinal cord stimulation for autonomic function recovery

The purpose of this study is to investigate the effects of non-invasive transcutaneous spinal cord stimulation (TCSCS) on cardiovascular, bladder, bowel and sexual function in people with spinal cord injury. The study team is interested in the immediate, long-term and longer-term effects (eight weeks after cessation of therapy) of non-invasive stimulation on these functions.

Status
Recruiting
Principal Investigator
Andrei Krassioukov
Body Locations and Systems
Blood, Heart and Circulation
Brain and Nerves
Kidneys and Urinary System
Men's and Women's Health
Age
18-60

Assessing the efficacy of a drug in preventing kidney transplant rejection

The purpose of this study is to assess the overall efficacy, safety and tolerability of BIVV020 for prevention and treatment of antibody-mediated rejection in adult kidney transplant recipients.

Status
Recruiting
Principal Investigator
John Gill
Body Locations and Systems
Kidneys and Urinary System
Age
18 and above

Developing a strategy to prevent hepatitis C virus reinfection

The purpose of this study is to measure patterns of hepatitis C virus (HCV) reinfection after achieving an undetectable viral load at end of treatment on direct-acting aniviral therapy; to determine the threshold of risk reduction practices that protects against HCV reinfection after achieving an undetectable viral load; and to evaluate the potential impact of successful HCV treatment in terms of health care costs and resource utilization.

Status
Recruiting
Body Locations and Systems
Endocrine System
Kidneys and Urinary System
Age
19 and above

Characterizing immune response to kidney transplantation

The purpose of this study is to characterize a recipient's immune system response to kidney transplantation to uncover an immune signature of early graft rejection.

Status
Recruiting
Principal Investigator
Paul Keown
Body Locations and Systems
Immune System
Kidneys and Urinary System

Improving antigen matching for renal transplant patients

The purpose of this study is to establish a protocol for improved human leukocyte antigen (HLA) matching for renal transplant patients.

Status
Recruiting
Principal Investigator
Paul Keown
Body Locations and Systems
Immune System
Kidneys and Urinary System
Age
18 and above

Burden of using intermittent catheters in people with spinal cord injury

The purpose of this study is to obtain a realistic picture of the microbiological burden associated with catheter re-use, provide evidence for time spent on bladder management and provide evidence for time spent cleaning catheters for re-use.

Recruitment Poster

Status
Recruiting
Principal Investigator
Andrei Krassioukov
Body Locations and Systems
Brain and Nerves
Kidneys and Urinary System

QPI-1002 for Prevention of Delayed Graft Function in Recipients of an Older Donor Kidney Transplant (ReGIFT)

The purpose of this trial is to evaluate the reduction in incidence and severity of delayed graft function with kidney allografts from donors >45 years after brain death (DBD).

Status
Recruiting
Principal Investigator
Jagbir Gill
Body Locations and Systems
Kidney Transplantation
Area
Vancouver
Age
18 and above

Evaluating coronary artery disease screening for kidney transplant candidates

The purpose of this study is to determine if coronary artery disease (CAD) screening is necessary for patients on the waiting list for kidney transplantation. Patients on the waiting list for kidney transplantation are at risk for CAD. Currently, patients without any symptoms of CAD undergo annual testing to determine if they have disease. The optimal strategy to monitor and maintain the cardiac fitness of these patients is unknown.

Status
Recruiting
Principal Investigator
Jagbir Gill
Body Locations and Systems
Blood, Heart and Circulation
Coronary Artery Disease
Kidneys and Urinary System
Area
Vancouver
Age
18 and above

A Study of Vonapanitase (PRT-201) Administered Immediately After Radiocephalic Arteriovenous Fistula(AVF) Creation in Patients With Chronic Kidney Disease (CKD) (PATENCY-2)

This research study is designed to assess the safety and effectiveness of an experimental drug called vonapanitase (PRT-201) in patients who have chronic kidney disease and who are undergoing surgery to create a new access point to their bloodstream for hemodialysis. Vonapanitase is a protein that has been shown in previous research studies to help keep vessels patent when applied to the outside surface of the blood vessels (arteries and veins) in patients who undergo surgery to create an arteriovenous fistula (AVF).

Status
Recruiting
Principal Investigator
Jerry Chen
Body Locations and Systems
Kidney Disease
Area
Vancouver
Age
18-100

Once Daily Dosing to Improve Medication Adherence and Patient Satisfaction in Kidney Transplant Recipients (OnceDaily)

Patient failure to take medications as prescribed (medication non-adherence) is now identified as an important cause of kidney transplant failure. The availability of new drugs that are taken once daily may improve patient adherence compared to older drugs that had to be taken twice per day. In this study, patients will be converted to a medication schedule where all medications are taken once daily with the goal of improving patient adherence and satisfaction.

Status
Recruiting
Principal Investigator
John Gill
Body Locations and Systems
Kidney Transplantation
Area
Vancouver
Age
18 and above

Calcium Supplements Strategy for Kidney Stones Prevention in Crohn's Patients

Hospitalization for kidney stones in the Inflammatory Bowel Disease (IBD) population is common, particularly among Crohn's patients who had a small bowel resection. This patient population experiences a lifetime occurrence of kidney stone formation as high as 25% accompanied with a high rate of recurrence (the typical rate of stone formation is ~10% in the non IBD population). Giving oral calcium is used to bind oxalate in the intestine in an attempt to reduce the amount of oxalate that is absorbed into the body and to reduce urinary oxalate levels.

Status
Recruiting
Principal Investigator
Ben Chew
Body Locations and Systems
Kidney Stones
Crohn's Disease
Area
Vancouver
Age
19 and above

Struvite Antibiotic Study

The aim of this research is to determine an effective antibiotic regimen following definitive surgical therapy of kidney stones caused by bacterial infection (struvite stones).

Status
Recruiting
Principal Investigator
Ben Chew
Body Locations and Systems
Kidney Stones
Area
Vancouver
Age
19 and above

A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL])

Percutaneous nephrolithotomy (PCNL) is a surgical procedure that is standard of care for the removal of large kidney stones. PCNL involves removal of the stone(s) from the kidney through a temporary tract that is percutaneously placed through the patient's back during surgery. There is a significant risk of urinary tract infection after PCNL but wide clinical variation in use of prophylactic antibiotics in the days leading up to surgery.

Status
Recruiting
Principal Investigator
Ben Chew
Body Locations and Systems
Kidney Stones
Urinary Tract Infections
Area
Vancouver
Age
18 and above

Urine and Stool Analysis in Kidney Stone Disease

The purpose of this study is to add to the investigators' quest to understanding stone disease, by evaluating the metabolites excretion in urine and its relation to microflora present in the stool.

Status
Recruiting
Principal Investigator
Ben Chew
Body Locations and Systems
Kidney Stones
Area
Vancouver
Age
19-90

A Pilot Study Comparing the Use of Low-target Versus Conventional Target Advagraf (Astellas)

While the incidence of acute rejection and early graft loss have improved dramatically with the advent of newer immunosuppressant medications, improvements in long-term patient and allograft survival after kidney transplantation have not been achieved. The specific drug combination that provides the best outcomes with the least amount of side effects is not known. Each kidney transplant center uses the combination of drugs that they believe is optimal.

Status
Recruiting
Principal Investigator
Jagbir Gill
Body Locations and Systems
Kidney Transplantation
Area
Vancouver
Age
19 and above

Closed for Recruitment

Improving bladder dysfunction with spinal cord neuromodulation therapy

The purpose of this study is to evaluate the effectiveness and safety of a spinal cord neuromodulation (SCONE) therapy in improving symptoms of neurogenic lower urinary tract dysfunction, as compared to an inactive sham control.

Status
Closed for Recruitment
Principal Investigator
Andrei Krassioukov
Body Locations and Systems
Brain and Nerves
Kidneys and Urinary System
Age
18-75

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