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  3. Neurologic Diseases

Neurologic Diseases

Recruiting

A Double-masked, Placebo-controlled Study With Open Label Period to Evaluate MEDI-551 in Neuromyelitis Optica and Neuromyelitis Optica Spectrum Disorders

To compare the efficacy of MEDI-551 versus placebo in reducing the risk of an NMO/NMOSD attack in subjects with NMO/NMOSD.

Status
Recruiting
Principal Investigator
Robert Carruthers
Body Locations and Systems
Neurologic Diseases
Vision Impairment and Blindness
Area
Vancouver
Age
18 and above

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)

The purpose of this study is to assess the safety, tolerability, biomarker and cognitive efficacy of investigational products in subjects who are known to have, or are at risk of having an Alzheimer's disease-causing mutation by determining if treatment with the study drug slows the rate of progression of cognitive impairment and improves disease-related biomarkers.
This study also offers an observational component collecting cognitive assessment data until the availability of an enrolling drug treatment group, referred to as cognitive run-in (CRI).

 

Status
Recruiting
Principal Investigator
Ging-Yuek Robin Hsiung
Body Locations and Systems
Alzheimer's Disease
Neurologic Diseases
Dementia
Area
Vancouver
Age
18-80

Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)

Frontotemporal Lobar Degeneration (FTLD) is the neuropathological term for a collection of rare neurodegenerative diseases that correspond to four main overlapping clinical syndromes: frontotemporal dementia (FTD), primary progressive aphasia (PPA), corticobasal degeneration syndrome (CBS) and progressive supranuclear palsy syndrome (PSPS). The goal of this study is to build a FTLD clinical research consortium to support the development of FTLD therapies for new clinical trials.

Status
Recruiting
Principal Investigator
Ian R.A. Mackenzie
Body Locations and Systems
Neurologic Diseases
Area
Vancouver
Age
18-85

Closed for Recruitment

Cognitive Brain Training in Older Adults

The investigators will conduct a 8-week proof-of-concept randomized controlled trial to provide preliminary evidence of efficacy of Fit Brains (Rosetta Stone Canada) training—a mobile cognitive training program—on cognitive and brain plasticity in older adults. The investigators will also explore whether Fit Brains training paired with a brief bout of exercise would enhance the potential cognitive benefits of Fit Brains.

Recruitment Poster

Status
Closed for Recruitment
Principal Investigator
Teresa Liu-Ambrose
Body Locations and Systems
Neurologic Diseases
Area
Vancouver
Age
65-85

Biologic Basis for Multiple Sclerosis Disease Progression in RRMS Patients Treated With Gilenya (IGLOO)

This study will determine whether in RRMS patients receiving Gilenya there is a link between disease progression and biologic markers.

Status
Closed for Recruitment
Principal Investigator
Anthony Traboulsee
Body Locations and Systems
Multiple Sclerosis
Neurologic Diseases
Area
Vancouver
Age
18-65
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