The purpose of this study is to assess the efficacy of two dose levels of brepocitinib in comparison to placebo, in adults with dermatomyositis.
The purpose of this study is to assess the efficacy of two dose levels of brepocitinib in adults with dermatomyositis compared to a placebo. After 52 weeks of double-blind treatment, participants have the option to continue therapy in a 52-week, open-label extension phase where all participants will receive brepocitinib.
The purpose of this study is to investigate the accuracy of a new telerehabilitation system, the PhysViz, by comparing it to an older method using standard clinic-based equipment known as the Biodex. Specifically, the team will be studying whether the amount of strain in the Achilles tendon measured is the same in both systems. Knowledge gained from this research will help the team develop future studies to test out the effectiveness of the tool for home-based strength training.
The purpose of this study is to assess the efficacy of the home-based Otago Exercise Program compared with usual care in reducing fall risk among older adults with mild cognitive impairment and a fall-related hip fracture.
The purpose of this study is to test two methods of delivering the Otago Exercise Program, which consists of strength and balance training delivered by a physiotherapist to seniors to help reduce falls and the risk of falls.
The purpose of this study is to examine the safety of running for knee joint health through an assessment of running biomechanics and MRI-derived measures of cartilage composition.
Study to Assess the Efficacy and Safety of VX-210 in Subjects With Acute Traumatic Cervical Spinal Cord Injury
This is a Phase 2b/3 study. The purpose of a 2b/3 study is to learn more about the safety and effects of VX-210 in patients with acute traumatic cervical SCI. VX-210 is an investigational drug; “in
The overall purpose of this study is to assess the feasibility of a cross-country non-inferiority randomized controlled trial (RCT) comparing midline sparing decompression alone (MSDA) to usual care (decompression with fusion).
Many individuals with cervical spinal cord injury (SCI) have difficulty using their hands and arms. MyndMove is a non-invasive medical device that uses short, low energy electrical pulses with surface electrodes to cause muscle contractions to produce a full range of reaching and grasping movements, which the patient is unable to perform by him/herself.
By using MyndMove therapy to help the individual move their arms and hands as he/she attempts to carry out typical reaching and grasping movements, the individual improves their ability to perform these tasks voluntarily.
The aim of this study is to develop an on-line eLearning self-management program to help people with osteoarthritis deal with employment issues and stay employed.
SuPRA: Using Wearable Activity Trackers With a New Application to Improve Physical Activity in Knee Osteoarthritis
Physical activity is an essential first-line treatment for patients with knee osteoarthritis (OA). However, only 13% of patients meet the activity recommendation of 150 minutes or more per week. The primary goal of this randomized controlled trial is to assess the efficacy of a Fitbit Flex (a wireless physical activity tracking device) paired with a new application, plus a brief education session and telephone counselling by a physiotherapist (PT), to improve physical activity and reduce sedentary time in patients with knee osteoarthritis.
HIP ATTACK is an international randomized controlled trial of 1200 patients with a hip fracture that requires a surgical intervention. This trial will determine the effect of accelerated medical clearance and accelerated surgery compared to standard care on the 30-day risk of a major perioperative complication (i.e., a composite of mortality, nonfatal myocardial infarction, nonfatal pulmonary embolism, nonfatal pneumonia, nonfatal sepsis, nonfatal stroke, and nonfatal life-threatening and major bleeding).
At the Falls Prevention Clinic, each subject receives a comprehensive assessment of his or her individual risk factors for falling in addition to a comprehensive medical examination. Recommendations and appropriate follow up tests and referrals are ordered for patients on an individual basis.
Reamer Irrigator Aspirator (RIA) vs Autogenous Iliac Crest Bone Graft (AICBG) for the Treatment of Non-unions
The specific question the investigators will seek to answer is: can the Reamer Irrigator Aspirator (RIA) provide a bone graft source for the treatment of nonunions that is equally effective to Autogenous Iliac Crest Bone Graft (AICBG) while resulting in a decreased amount of post-operative pain and a lower rate of complications?
Collaborative Power Mobility Innovative Learning OpporTunity (CoPILOT) - A Pilot Study of a New Training Approach (Phase 1) (CoPILOT)
Losing the ability to walk can lead to fewer opportunities to socialize with friends and family, and participate in the community. When this happens, powered wheelchairs can provide access to homes and communities, contributing to health and well-being. Training by a qualified occupational therapist allows an individual to use a powered wheelchair safely and effectively. Learning to drive a powered wheelchair can be difficult, frustrating and time consuming for people with cognitive and physical challenges.
Closed for Recruitment
The Hip Health Information Project (HHIP) is a study investigating the experiences and perceptions of pre-surgical education to prepare patients with osteoarthritis (OA) of the hip for hip replacement surgery. The purpose of this study is to explore, through focus groups, the barriers and opportunities that exist for improving education programs for OA hip patients.
To assess if thigh muscle activation is different in women with knee pain compared to those without knee pain
Tibia-fibular syndesmosis injury occurs in a significant proportion of ankle injuries and is assumed to disrupt the syndesmotic ligaments.
This proof-of-concept randomized trial evaluates the effectiveness of using an on-line decision aid (ANSWER-2) in the decision making to start or switch biologic therapy in Canadian patients with rheumatoid arthritis.
Being physically active can reduce pain and fatigue, improve mobility and enhance quality of life in people with arthritis, but adherence to an active lifestyle is poor, with less than half of people with arthritis being active. The primary goal of this randomized controlled trial is to assess the efficacy of a physical activity coaching model to improve physical activity participation and reduce sedentary time in patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus.