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  2. Research
  3. Lakshmi Yatham

Lakshmi Yatham

Professor
VCH Clinical Title(s)
Psychiatrist
Research Focus
Brain and Nerves Mental Health and BehaviourBipolar DisorderDepression
Degrees / Designations

MBBS, FRCPC, MRCPsych

Contact Info
l.yatham@ubc.ca
604-822-0562
LakshmiYatham

Biography

Dr. Lakshmi Yatham is a member of the Djavad Mowafaghian Centre for Brain Health, the director of the Institute of Mental Health and a professor and the head of the Department of Psychiatry at the University of British Columbia (UBC). He is also the regional head of psychiatry and regional program medical director for mental health and addictions at Vancouver Coastal Health and Providence Health Care. He has an executive MBA in health care from the Sauder School of Business.

Dr. Yatham’s areas of research interest include neurobiology and treatment of bipolar disorders. He has published close to 450 papers in peer-reviewed international journals including New England Journal of Medicine, World Psychiatry, Lancet Psychiatry, Nature Mental Health and JAMA Psychiatry with over 40,000 citations to his work.
 

Research Studies

Bipolar Disorder, Brain and Nerves, Mental Health and Behaviour

Investigating psilocybin to treat depression in bipolar II disorder

Brain and Nerves, Mental Health and Behaviour

Investigating the effectiveness of CBD for bipolar depression

Bipolar Disorder, Bipolar Disorder, Mental Health and Behaviour, Men's and Women's Health

Study of the Efficacy of Lurasidone in Cognitive Functioning in Bipolar Patients (ELICE_BD)

Bipolar Disorder, Depression, Bipolar Disorder, Depression

Bipolar Depression and the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS)

Bipolar Disorder, Bipolar Disorder, Mental Health and Behaviour

Mood Stabilizer (MS)+ Antidepressant vs MS + Placebo in Maintenance of Bipolar Disorder

News and Awards

Helping people with bipolar disorder see their cognitive strengths

Aug 22, 2025

Discovering the likely cause of manic symptoms in bipolar disorders

Mar 31, 2023

A brighter future with bipolar disorder

Apr 4, 2018

Publications

  • The lancet. Psychiatry -

    Lithium as a disease-modifying drug for bipolar disorder.

    Post RM, Li VW, Berk M, Yatham LN
  • The New England journal of medicine -

    Duration of Adjunctive Antidepressant Maintenance in Bipolar I Depression.

    Yatham LN, Arumugham SS, Kesavan M, Ramachandran K, Murthy NS, Saraf G, Ouyang Y, Bond DJ, Schaffer A, Ravindran A, Ravindran N, Frey BN, Daigneault A, Beaulieu S, Lam RW, Kondapuram N, Reddy MS, Bhandary RP, Ashok MV, Ha K, Ahn YM, Milev R, Wong H, Reddy YCJ,
  • The British journal of psychiatry : the journal of mental science -

    Duration of untreated or undiagnosed bipolar disorder and clinical characteristics and outcomes: systematic review and meta-analysis.

    Keramatian K, Pinto JV, Tsang VWL, Chakrabarty T, Yatham LN
  • Bipolar disorders -

    Cariprazine as a maintenance therapy in the prevention of mood episodes in adults with bipolar I disorder.

    McIntyre RS, Davis B, Rodgers J, Rekeda L, Adams J, Yatham LN
  • Psychological medicine -

    Brain age and cognitive functioning in first-episode bipolar disorder.

    Chakrabarty T, Frangou S, Torres IJ, Ge R, Yatham LN
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