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  3. Depression

Depression

Recruiting

Predicting treatment outcomes for major depression

The purpose of this study is to test whether a specific combination of biomarkers discovered during previous studies can help predict how someone experiencing a major depressive episode will respond to treatment. The study will also explore other possible biomarkers that may predict treatment response, which may help in the future development of tests that can guide treatment choice more effectively and more quickly.

Status
Recruiting
Principal Investigator
Raymond Lam
Body Locations and Systems
Brain and Nerves
Age
18-60

Evaluating the feasibility of non-medication treatments for depression

The purpose of this study is to explore the use of two separate non-medication treatments, light therapy and ion therapy, as substitutes for antidepressants for maintenance treatment in major depression. More information on the study can be found at reachbc.ca.

Status
Recruiting
Principal Investigator
Raymond Lam
Body Locations and Systems
Brain and Nerves
Age
19-65

PORT Trial

The purpose of this study is to evaluate the feasibility of using repetitive transcranial magnetic stimulation (rTMS) to treat depression. 

Status
Recruiting
Principal Investigator
Fidel Vila-Rodriguez
Body Locations and Systems
Brain
Area
Vancouver
Age
18 and above

Developing a risk assessment tool for discriminating social cognition deficits in dementia from that of depression

To look at the differences in "social cognition"- the ability to look at the interpret the social world and put yourself in someone else's shoes - between people with depression, people with frontotemporal dementia and healthy controls.

Status
Recruiting
Principal Investigator
Howard Feldman
Body Locations and Systems
Dementia
Depression
Area
Vancouver
Age
40-80

Repetitive Transcranial Magnetic Stimulation in the Treatment of Major Depressive Disorder

This trial will compare a novel form of rTMS, intermittent Theta Burst Stimulation to the standard conventional high frequency left sided stimulation protocol. The Left dorsolateral prefrontal cortex will be the site of stimulation in both treatment conditions. The site of stimulation will be targeted using MRI co-registration.

Status
Recruiting
Principal Investigator
Fidel Vila-Rodriguez
Body Locations and Systems
Depression
Area
Vancouver
Age
51-60

Closed for Recruitment

Canadian Biomarker Integration Network for Depression (CAN-BIND) - Validation Study

The purpose of this study is to learn about biomarkers (biological features such as proteins, genes, and brain images that indicate the state of a disease in a person), and how they can help predict treatment outcomes in patients with clinical depression. 

Status
Closed for Recruitment
Principal Investigator
Raymond Lam
Body Locations and Systems
Depression
Area
Vancouver
Age
18-60

Bipolar Depression and the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS)

The purpose of this study is to assess the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS), a non-invasive (does not enter the body) technique in improving depressive symptoms.

Recruitment Poster

Status
Closed for Recruitment
Principal Investigator
Lakshmi Yatham
Body Locations and Systems
Bipolar Disorder
Depression
Area
Vancouver
Age
18-70

Canadian rTMS Treatment and Biomarker Network in Depression Trial (CARTBIND)

Repetitive transcranial magnetic stimulation (rTMS) is an emerging treatment for medically refractory major depressive disorder (MDD). rTMS involves direct stimulation of cortical neurons using externally applied, powerful, focused magnetic field pulses. Dozens of studies and several meta-analyses over the last 15 years have shown that rTMS of the dorsolateral prefrontal cortex (DLPFC) produces statistically significant improvements in MDD, even when medications have failed. However, other possible targets may also yield improvement in symptoms.

Status
Closed for Recruitment
Principal Investigator
Fidel Vila-Rodriguez
Body Locations and Systems
Depression
Area
Vancouver
Age
18-59

tDCS in Parkinson's Disease With Depression

Parkinson's disease (PD) is a progressive neurological disease that has effects on both movement and mental health. One of the most common mental health complications of PD is depression. Up to 30% of Parkinson's patients will experience depression at some point. We aim to investigate whether transcranial direct current stimulation (tDCS), a type of electrical stimulation for the brain, can improve depression in PD as well as improve motor function in PD.

Status
Closed for Recruitment
Principal Investigator
Jon Stoessl
Body Locations and Systems
Depression
Parkinson's Disease
Area
Vancouver
Age
19 and above

Canadian Biomarker Integration Network for Depression Study (CAN-BIND-1)

This study is a pilot to assess feasibility of the protocol in patients and controls across six participating sites. The goal is to identify biological markers (biomarkers)that can be measured at baseline or early in treatment to predict treatment outcome in individual patients with Major Depressive Disorder (MDD). Biomarkers of interest will be clinical (using interview and self-report measures), molecular (from blood samples) and neurobiological (using neuroimaging and EEG).


 

Status
Closed for Recruitment
Principal Investigator
Raymond Lam
Body Locations and Systems
Depression
Area
Vancouver
Age
18-60
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