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  3. Bipolar Disorder

Bipolar Disorder

Closed for Recruitment

Study of the Efficacy of Lurasidone in Cognitive Functioning in Bipolar Patients (ELICE_BD)

This is a randomized, double-blind, placebo-controlled, multicentre, parallel-group study to assess the cognitive effects of lurasidone in bipolar I and II patients (manic depression) who are in remission from an episode. Participants who show cognitive impairment at the screening visit will be enrolled into the study and randomized at the baseline visit to receive either lurasidone or placebo adjunctive therapy in a 1:1 ratio for 6 weeks.

Recruitment Poster

Status
Closed for Recruitment
Principal Investigator
Lakshmi Yatham
Body Locations and Systems
Bipolar Disorder
Men's and Women's Health
Area
Vancouver
Age
19-65

Bipolar Depression and the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS)

The purpose of this study is to assess the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS), a non-invasive (does not enter the body) technique in improving depressive symptoms.

Recruitment Poster

Status
Closed for Recruitment
Principal Investigator
Lakshmi Yatham
Body Locations and Systems
Bipolar Disorder
Depression
Area
Vancouver
Age
18-70

Mood Stabilizer (MS)+ Antidepressant vs MS + Placebo in Maintenance of Bipolar Disorder

Patients with bipolar I disorder (BD) experience depression 3 times more frequently than mania, and antidepressants are prescribed as adjuncts to mood stabilizers in up to 70% of patients. However, no placebo-controlled trials have assessed the efficacy or safety of modern antidepressants in combination with mood stabilizers in the maintenance treatment of BD. The investigators propose a multicentre, randomized, double-blind clinical trial comparing mood stabilizer plus antidepressant (escitalopram or bupropion XL) to mood stabilizer plus placebo in the maintenance treatment of BD.

Status
Closed for Recruitment
Principal Investigator
Lakshmi Yatham
Body Locations and Systems
Bipolar Disorder
Area
Vancouver
Age
18-70
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