Research Study

Canadian rTMS Treatment and Biomarker Network in Depression Trial
Principal Investigator 
Fidel Vila-Rodriguez

Overview

Body Locations and Systems 
Depression
Disorders and Conditions 
Depression
ClinicalTrials.gov# 
NCT02729792
Status 
Recruiting
Study Start/End 
May 9, 2016 to Jun 30, 2018
Locations 
UBC Hospital
Name/Title 
Jennifer Brown, Study Coordinator
Phone 
604-827-1361
Email Address 
ninet.lab@ubc.ca
Purpose of Study 

Repetitive transcranial magnetic stimulation (rTMS) is an emerging treatment for medically refractory major depressive disorder (MDD). rTMS involves direct stimulation of cortical neurons using externally applied, powerful, focused magnetic field pulses. Dozens of studies and several meta-analyses over the last 15 years have shown that rTMS of the dorsolateral prefrontal cortex (DLPFC) produces statistically significant improvements in MDD, even when medications have failed. However, other possible targets may also yield improvement in symptoms.

In an attempt to enhance the therapeutic efficacy of current interventions for TRD, attention has turned to identifying domain-specific biomarkers in hopes of ultimately individualizing and predicting treatment response. Unfortunately, the precise nature of this relationship is less than clear, as reflected by the fact that even now there are no established biomarkers that are used routinely in clinical practice to aid in diagnosis. This study also seeks to examine a comprehensive suite of biomarker measurements (MRI, neurophysiology, and genomics/proteomics) before and after rTMS treatment.

Recruitment poster

Eligibility 

 

Visit ClinicalTrials.gov for more information.

Disclaimer 

Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers and email addresses are provided for obtaining additional information on specific clinical research trials only. If you have specific questions which require clinical expertise, please call your primary care physician.