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Heart

Recruiting

Promoting sleep quality in chronic stroke with exercise

The purpose of the study is to determine whether a 26-week exercise training program or cognitive training program can improve sleep quality in stroke survivors who are experiencing poor sleep quality.

Status
Recruiting
Principal Investigator
Teresa Liu-Ambrose
Body Locations and Systems
Stroke
Bones, Joints and Muscles
Brain and Nerves
Age
55 and above

Investigating blood thinners for atrial fibrillation after surgery

The purpose of this study is to assess the effects of blood thinners in patients who develop short-term atrial fibrillation during surgery, and to determine whether blood thinners can lower the risk of stroke in this population. 

Status
Recruiting
Body Locations and Systems
Blood, Heart and Circulation
Arrhythmia
Atrial Fibrillation
Age
55 and above

Understanding the experiences of young women stroke survivors

The purpose of this study is to identify gaps in health services and make recommendations for the development of high-quality and equitable systems of stroke care informed by young women stroke survivors' experiences.

To participate in this study, complete the online form.

Status
Recruiting
Principal Investigator
Sally Thorne
Body Locations and Systems
Stroke
Brain and Nerves
Age
18-60

Testing the effectiveness of cardiac resynchronization therapy in heart failure

The purpose of this study is to test the comparative effectiveness of two types of cardiac resynchronization therapy (CRT) lead implantations (His vs LBBP) in relation to patient-centered outcomes (e.g. quality of life, physical activity, heart failure hospitalization, mortality) and comparative safety in relation to device-related complications and re-interventions (e.g. lead dislodgement, infection) relative to standard of care biventricular pacing.

Status
Recruiting
Principal Investigator
Jason Andrade
Body Locations and Systems
Blood, Heart and Circulation
Heart Failure
Age
18 or above

CAN-ACCESS

The purpose of the study is to find the best technique and tools for gaining access to left and right heart arteries using x-rays that show blood flow, in patients who are having a specific Medtronic heart valve inserted.

Status
Recruiting
Principal Investigator
Janarthanan Sathananthan
Body Locations and Systems
Heart
Area
Vancouver
Age
18 and above

Dapagliflozin and Effect on Cardiovascular Events in Acute Heart Failure -Thrombolysis in Myocardial Infarction 68 (DAPA ACT HF-TIMI 68)

The purpose of the study is to evaluate the effect of in-hospital initiation of dapagliflozin versus placebo on the clinical outcome of cardiovascular death or worsening heart failure.

Status
Recruiting
Principal Investigator
Graham Wong
Body Locations and Systems
Heart Failure
Area
Vancouver
Age
18 and above

Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE)

The purpose of the study is to compare differences in blood flow and valve pressures by two different methods in patients who are having transcatheter aortic valve replacement.

Status
Recruiting
Principal Investigator
David Wood
Body Locations and Systems
Heart Disease
Area
Vancouver

Creation and Implementation of a BC/Canada Registry for Familial Hypercholesterolemia

Familial hypercholesterolemia (FH) is the most frequent genetic lipoprotein disorder associated with premature coronary artery disease.  The goal of this initiative is to create a registry of subjects with FH across Canada. The registry will help clinicians and researchers to determine the burden of disease and the long-term effects of treatment. 

Status
Recruiting
Principal Investigator
Liam Brunham
Body Locations and Systems
Coronary Artery Disease
Area
Vancouver

MANTA Vascular Closure Device Clinical Study (MANTA)

Research study which tests the safety and effectiveness of a new vascular closure device to close the femoral access puncture that is created in patients who require this form of access in order to perform the planned procedure. The MANTA device is expected to seal the femoral access puncture in less than 1 minute. This may result in less blood loss and a shorter time to walking compared to alternative closure means. Use of the MANTA device in this study is experimental. All other parts of the procedure involve standard medical care

Status
Recruiting
Principal Investigator
David Wood
Body Locations and Systems
Heart
Area
Vancouver
Age
21 years and above

PULSE (Partners Using Linked Strategies Effectively) Study

Health behaviors like physical activity and nutritious eating habits significantly reduce initial stroke risk and help prevent strokes from reoccurring. Yet, most individuals struggle to meet physical activity and nutrition recommendations. Health and health behaviors are typically linked in couples, and spouses occupy a unique position to facilitate each other’s physical activity and healthy nutrition, thereby reducing stroke risk for everyone involved. 

Status
Recruiting
Principal Investigator
Christiane Hoppmann
Body Locations and Systems
Stroke
Area
Vancouver

AMPLATZER™ LAA Occluder Post Approval Study (PAS)

The AMPLATZER LAA Occluder is a transcatheter, self-expanding nitinol device intended for use in preventing thrombus embolization from the LAA. The purpose of this study is to compile real world outcome data on the use of AMPLATZER LAA Occluder in subjects with non-valvular atrial fibrillation (NVAF)

Status
Recruiting
Principal Investigator
Jacqueline Saw
Body Locations and Systems
Atrial Fibrillation
Stroke
Area
Vancouver
Age
18 and above

Putting Heart Failure Patient's Experiences at the Centre of Home Health Monitoring Design

We hope to understand a heart failure patient's journey during the transition of care from the emergency department or hospital to home. We also want to explore how technology, like home health monitoring, can better support patients' recovery during this time.

Recruitment Poster

Status
Recruiting
Principal Investigator
Chad Kim Sing
Body Locations and Systems
Heart Failure
Area
Vancouver
Age
all ages

Evaluating coronary artery disease screening for kidney transplant candidates

The purpose of this study is to determine if coronary artery disease (CAD) screening is necessary for patients on the waiting list for kidney transplantation. Patients on the waiting list for kidney transplantation are at risk for CAD. Currently, patients without any symptoms of CAD undergo annual testing to determine if they have disease. The optimal strategy to monitor and maintain the cardiac fitness of these patients is unknown.

Status
Recruiting
Principal Investigator
Jagbir Gill
Body Locations and Systems
Blood, Heart and Circulation
Coronary Artery Disease
Kidneys and Urinary System
Area
Vancouver
Age
18 and above

Trial of Electrical Versus Pharmacological Cardioversion for RAFF in the ED (RAFF-2)

Atrial fibrillation (AF) and atrial flutter (AFL) are cardiac rhythm problems where there is an irregular, rapid heart rate. Investigators plan to study Emergency Department (ED) patients with recent-onset episodes of AF or AFL (RAFF) where rapid heart rate requires urgent treatment to restore normal heart rhythm. RAFF is the most common rhythm disorder managed in the ED. Investigators recently showed that doctors use a wide variety of treatment approaches in Canadian EDs for RAFF.

Status
Recruiting
Principal Investigator
Corinne Hohl
Body Locations and Systems
Atrial Fibrillation
Arrhythmia
Area
Vancouver
Age
16 and above

A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion (TEMPO-2)

This trial will enroll patients that have been diagnosed with a transient ischemic attack (TIA) or minor stroke that has occurred within the past 12 hours. Anyone diagnosed with a minor stroke faces the possibility of long-term disability and even death, regardless of treatment. Stroke symptoms such as weakness, difficulty speaking and paralysis may improve or worsen over the hours or days immediately following a stroke. TEMPO-2 is a minor stroke trial for patients presenting within 12 hours of their symptom onset. Patients will be randomized to TNK-tPA or standard of care.

Status
Recruiting
Principal Investigator
Thalia Field
Body Locations and Systems
Stroke
Stroke
Area
Vancouver
Age
18 and above

The CREST-2 Registry (C2R)

The objective of C2R is to promote the rapid initiation and completion of enrollment in the CREST-2 randomized clinical trial (clinicaltrials.gov ID NCT02089217). Patients with severe symptomatic and asymptomatic carotid artery occlusive disease will be treated with carotid artery stenting (CAS) performed by experienced and skilled interventionists. Interventionists' eligibility will be determined by a multi-specialty Interventional Management Committee (IMC). Patient eligibility will include patients with standard or high-risk, symptomatic or asymptomatic carotid artery disease.

Status
Recruiting
Principal Investigator
Philip A. Teal
Body Locations and Systems
Coronary Artery Disease
Area
Vancouver
Age
18-80

Blinded Randomized Trial of Anticoagulation to Prevent Ischemic Stroke and Neurocognitive Impairment in Atrial Fibrillation (BRAIN-AF)

This is a prospective, multicenter, randomized, double-blinded clinical trial exploring the efficacy and safety of rivaroxaban as compared to acetylsalicylic acid in reducing stroke, transient ischemic attack (TIA) and neurocognitive decline, in subjects with non-valvular AF and with low risk of stroke.

Status
Recruiting
Principal Investigator
Anthony Fung
Body Locations and Systems
Stroke
Atrial Fibrillation
Area
Vancouver
Age
30-60

Efficacy of Implantable Defibrillator Therapy After a Myocardial Infarction (REFINE-ICD)

This study will assess whether an implantable defibrillator will increase the likelihood of survival in patients who have had a heart attack in the prior year, have abnormal test results from a 24 hour heart monitor, and who have low normal heart function.

Status
Recruiting
Principal Investigator
Matthew Bennett
Body Locations and Systems
Heart Attack
Area
Vancouver
Age
18-80

Dabigatran Following Transient Ischemic Attack and Minor Stroke (DATAS II)

Rationale: To date, anticoagulant therapy in acute stroke has also been limited by excess hemorrhagic events. The oral anticoagulant dabigatran is a novel agent, which has been shown to be associated with much lower intracranial hemorrhage rates. It has been suggested that this agent may provide the superior benefits of anticoagulation in acute stroke, without the concomitant increase in hemorrhage risk associated with heparin/LMWH or warfarin.

Status
Recruiting
Principal Investigator
Thalia Field
Body Locations and Systems
Stroke
Area
Vancouver
Age
18 and above

Complete vs Culprit-only Revascularization to Treat Multi-vessel Disease After Primary PCI for STEMI (COMPLETE)

To determine whether, on a background of optimal medical therapy, including ticagrelor, opening of all suitable narrowings or blockages found at the time of primary PCI for an acute heart attack is better than treating only the culprit lesion in patients with multi-vessel disease.

Status
Recruiting
Principal Investigator
David Wood
Body Locations and Systems
Heart Attack
Area
Vancouver
Age
All ages

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