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Heart Attack

Recruiting

EMPACT-MI: A Study to Test Whether Empagliflozin Can Lower the Risk of Heart Failure and Death in People Who Had a Heart Attack (Myocardial Infarction)

The purpose of this study is to determine if the drugĀ empagliflozin helps to lower the chances of having to go to the hospital for heart failure and whether it lowers the chances of dying from cardiovascular disease.

Status
Recruiting
Principal Investigator
Christopher Fordyce
Body Locations and Systems
Heart Attack
Area
Vancouver
Age
18 and above

Women's Heart Attack Research Program- Imaging Study (HARP)

The Women's HARP study is a multi-center, diagnostic observational study employing standardized imaging protocols in women with MINOCA (MI with Non Obstructive Coronary Arteries) to determine the underlying diagnosis in each participant. Participants will be followed for recurrent clinical events, every 6 months, for a maximum of 3 years.

Status
Recruiting
Principal Investigator
Tara Sedlak
Body Locations and Systems
Heart Attack
Heart Disease in Women
Area
Vancouver
Age
21-99

INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure (INVESTED)

INVESTED will test the hypothesis that high dose trivalent influenza vaccine will reduce cardiopulmonary events to a greater extent than standard dose quadrivalent influenza vaccine in high-risk cardiovascular patients with a recent history of myocardial infarction or heart failure. The trial will enroll 9300 participants over one Vanguard (pilot) season and three additional influenza seasons. The primary endpoint will be a composite of all-cause mortality or cardiopulmonary hospitalization.

Status
Recruiting
Principal Investigator
Kenneth Gin
Body Locations and Systems
Heart Failure
Heart Attack
Area
Vancouver
Age
18 and above

Efficacy of Implantable Defibrillator Therapy After a Myocardial Infarction (REFINE-ICD)

This study will assess whether an implantable defibrillator will increase the likelihood of survival in patients who have had a heart attack in the prior year, have abnormal test results from a 24 hour heart monitor, and who have low normal heart function.

Status
Recruiting
Principal Investigator
Matthew Bennett
Body Locations and Systems
Heart Attack
Area
Vancouver
Age
18-80

Complete vs Culprit-only Revascularization to Treat Multi-vessel Disease After Primary PCI for STEMI (COMPLETE)

To determine whether, on a background of optimal medical therapy, including ticagrelor, opening of all suitable narrowings or blockages found at the time of primary PCI for an acute heart attack is better than treating only the culprit lesion in patients with multi-vessel disease.

Status
Recruiting
Principal Investigator
David Wood
Body Locations and Systems
Heart Attack
Area
Vancouver
Age
All ages

Closed for Recruitment

Canadian Spontaneous Coronary Artery Dissection (SCAD) Study

SCAD (Spontaneous coronary artery dissection - tear in the arterial wall that is not related to trauma) is an under-diagnosed and poorly understood condition that mostly affects young women without common cardiovascular risk factors, and can result in heart attack and death. This observational study is designed to capture the disease's natural history and predisposing arteriopathies (medical conditions resulting in changes in the arteries), treatment strategies, long-term cardiovascular outcomes.

Status
Closed for Recruitment
Principal Investigator
Jacqueline Saw
Body Locations and Systems
Heart Attack
Arteries
Area
Vancouver
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