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  3. Liver Cancer

Liver Cancer

Closed for Recruitment

Study of Pembrolizumab (MK-3475) as Monotherapy in Adults With Previously Systemically Treated Advanced Hepatocellular Carcinoma (MK-3475-224/KEYNOTE-224)

This is a efficacy and safety study of pembrolizumab (MK-3475, KEYTRUDA®) as monotherapy in participants with previously systemically treated hepatocellular carcinoma (HCC). Study participants may receive pembrolizumab once every 3 weeks for up to 35 administrations (up to approximately 2 years).

The primary objective of this study is to determine the Objective Response Rate (ORR) of pembrolizumab given as monotherapy in participants with previously systemically treated HCC. 

Status
Closed for Recruitment
Principal Investigator
Eric Yoshida
Body Locations and Systems
Cancer
Area
Vancouver
Age
18 and above

Efficacy Evaluation of TheraSphere in Patients With Inoperable Liver Cancer (STOP-HCC)

The safety and effectiveness of TheraSphere will be evaluated in patients with unresectable hepatocellular carcinoma in whom treatment with standard-of-care sorafenib is planned. All patients receive the standard-of-care sorafenib with or without the addition of TheraSphere.


 

Status
Closed for Recruitment
Principal Investigator
David Ming-Teh Liu
Body Locations and Systems
Liver
Area
Vancouver
Age
18 and above

Study of Tivantinib in Subjects With Inoperable Hepatocellular Carcinoma Who Have Been Treated With One Prior Therapy (METIV-HCC)

The purpose of this study is to determine if tivantinib (ARQ 197) is effective in treating patients with MET diagnostic-high hepatocellular carcinoma (liver cancer) who have already been treated once with another therapy.

Status
Closed for Recruitment
Principal Investigator
Alan Weiss
Body Locations and Systems
Cancer
Hepatitis C
Area
Vancouver
Age
18 and above
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