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  2. Participate in Research
  3. Assessing a drug to treat thyroid eye disease
Research Study

A Phase 1/2, Randomized, Double-Masked, Placebo-Controlled, Multicenter Study to Assess the Safety, Pharmacokinetics, and Efficacy of AMG 732 in Healthy Subjects and Subjects with Moderate-to-Severe Active Thyroid Eye Disease

Principal Investigator
Peter Dolman

Overview

Body Locations and Systems
Endocrine System
Thyroid
Eyes and Vision
ClinicalTrials.gov#
NCT06401044
Status
Recruiting
Start/End Dates
Dec 1, 2025
Locations
Eye Care Centre
Gordon and Leslie Diamond Health Care Centre
Name/Title
Levina Ira, Research Facilitator
Phone
604-875-4111 ext.62178
Email Address
levina.ira@vch.ca
Purpose of Study

The purpose of this study is to investigate the safety and tolerability of AMG 732 in participants with thyroid eye disease (TED). TED is an autoimmune disease in which the eye muscles and fatty tissue behind the eye become inflamed causing the eyeball to bulge.

In this masked study, participants who have TED will be randomly assigned to either AMG 732 or a placebo and will receive a total of six subcutaneous (under the skin) injections in the abdomen over the course of 20 weeks. There will be approximately 20 study visits for about one year in which participants will undergo assessments such as blood and urine sampling, questionnaires, eye exams, hearing tests and MRI.

Eligibility

Visit ClinicalTrials.gov for more information.

Disclaimer

Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers and email addresses are provided for obtaining additional information on specific research studies only. If you have specific questions which require clinical expertise, please call your primary care physician.

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