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  2. Participate in Research
  3. Evaluating the efficacy of a gene therapy to treat vision loss
Research Study

A Randomized, Partially Masked, Controlled, Phase 3 Clinical Study to Evaluate the Efficacy and Safety of RGX-314 Gene Therapy in Participants with nAMD

Principal Investigator
Eduardo Navajas

Overview

Body Locations and Systems
Eyes and Vision
ClinicalTrials.gov#
NCT05407636
Status
Recruiting
Start/End Dates
Oct 1, 2023 Aug 31, 2025
Locations
Eye Care Centre
Name/Title
Levina Ira, Study Coordinator
Phone
604-875-4111 ext.62178
Email Address
levina.ira@vch.ca
Purpose of Study

The purpose of this study is to evaluate the efficacy and safety of a novel gene therapy in participants with wet age-related macular degeneration (nAMD), a significant cause of vision loss for people worldwide. Current standard of care therapies require life-long intraocular injections that are typically repeated every 4-12 weeks to maintain efficacy. Due to the burden of treatment, patients often experience a decline in vision with reduced frequency of treatment over time. As such, gene therapy RGX-314 is being developed as a potential one-time treatment for nAMD.

Eligibility

Visit ClinicalTrials.gov for more information.

Disclaimer

Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers and email addresses are provided for obtaining additional information on specific research studies only. If you have specific questions which require clinical expertise, please call your primary care physician.

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