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  3. Megan Levings

Megan Levings

Professor
Academic Appointment
Professor
Research Focus
Immune System
Contact Info
bcchr.ca/levingslab
megan.levings@ubc.ca
604-875-2000 ext. 4686
mklevings.bsky.social
megan-levings/

Biography

Dr. Megan Levings is a professor in the Department of Surgery and the School of Biomedical Engineering at the University of British Columbia (UBC). Her lab studies how a special kind of white blood cell, known as a T regulatory cell, could be used as a cellular therapy to prevent harmful immune responses. She leads a vibrant group of trainees and staff who are researching how to use T regulatory cells to replace conventional immunosuppression in transplantation and autoimmunity. She is also the project lead for the Advanced Therapeutics Manufacturing Facility, which is UBC’s new Good Manufacturing Practice facility projected to open in 2028. 
 
Dr. Levings has received numerous awards, including the Canadian Society for Immunology Cinader Award and the YWCA Woman of Distinction, Science, Research & Technology. She is internationally recognized in the field of human immunology and is currently the president of the Federation of Clinical Immunology Societies. 

Publications

  • Cell stem cell -

    Tunable differentiation of human CD4{{sup}}+{{/sup}} and CD8{{sup}}+{{/sup}} T cells from pluripotent stem cells.

    Jones RD, Salim K, Stankiewicz LN, Edgar JM, Leon L, Gillies JK, Murtaza A, Durland LJ, Raval D, Lau C, Taberna TPB, Hsu HH, Zimmerman C, Michaels YS, Rossi FMV, Levings MK, Zandstra PW
  • Cell reports. Medicine -

    TYK2 inhibition enhances Treg differentiation and function while preventing Th1 and Th17 differentiation.

    Tuomela K, Garcia RV, Boardman DA, Tavakoli P, Ancheta-Schmit M, Sham HP, Cheng L, Struthers M, Bressler B, Vallance BA, Zhao Q, Levings MK
  • Science translational medicine -

    CAR T{{sub}}reg{{/sub}} cells mediate linked suppression and infectious tolerance in islet transplantation in mice.

    Wardell CM, Fung VCW, Chen E, Haque M, Tan DFH, Leca M, Gillies J, Spanier JA, Mojibian M, Fife BT, Levings MK
  • Science advances -

    Armored human CAR T{{sub}}reg{{/sub}} cells with PD1 promoter-driven IL-10 have enhanced suppressive function.

    Boardman DA, Mangat S, Gillies JK, Leon L, Fung VCW, Haque M, Mojibian M, Halvorson T, Huang Q, Tuomela K, Wardell CM, Brown A, Lam AJ, Levings MK
  • Nature reviews. Drug discovery -

    Harnessing the biology of regulatory T cells to treat disease.

    Wardell CM, Boardman DA, Levings MK
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