Research Study

A Phase IIa Multi-Center Study of 18F-FDG PET, Safety, and Tolerability of AZD0530 in Mild Alzheimer's Disease
Principal Investigator 
Haakon Nygaard


Body Locations and Systems 
Alzheimer's Disease
Disorders and Conditions 
Alzheimer's Disease 
Closed for Recruitment
Study Start/End 
Oct 6, 2015 to Dec 31, 2017
UBC Hospital
Mannie Fan, Research Coordinator
Email Address
Purpose of Study 

AZD0530 is an inhibitor of Src and Abl family kinases1. It has been developed as treatment for malignancies because these kinases play a role in tumor invasion and proliferation. However, the Src family kinases (SFKs) are highly expressed in brain and have major effects on synaptic plasticity2. Moreover, the investigators have recently shown that a specific SFK, namely Fyn, is aberrantly activated by specific conformations of the Amyloid Beta (Aß) peptide from Alzheimer's disease (AD). Genetic deletion of Fyn rescues AD deficits in preclinical models. This clinical trial will test the potential benefit of AZD0530 for Alzheimer's disease modification.


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