A Phase 3 Open-label Randomized Study of Quizartinib (AC220) Monotherapy Versus Salvage Chemotherapy in Subjects With Tyrosine Kinase 3 - Internal Tandem Duplication (FLT3-ITD) Positive Acute Myeloid Leukemia (AML) Refractory to or Relapsed After First-line Treatment With or Without Hematopoietic Stem Cell Transplantation (HSCT) Consolidation
Principal Investigator
Donna E. HoggeOverview
Body Locations and Systems
LeukemiaDisorders and Conditions
ClinicalTrials.gov#
NCT02039726Status
Closed for RecruitmentStudy Start/End
Sep 19, 2014 to Jun 7, 2019Locations
Vancouver General HospitalName/Title
Jill Clark, Research NursePhone
604-875-4111 ext.62887Email Address
jclark@bccancer.bc.caPurpose of Study
The primary objective of the study is to determine whether quizartinib monotherapy prolongs overall survival (OS) compared to salvage chemotherapy in subjects with FMS-like tyrosine kinase 3 - Internal Tandem Duplication (FLT3-ITD) positive AML who are refractory to or have relapsed within 6 months, after first-line AML therapy.
Eligibility
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Disclaimer
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