Genetic Susceptibility to Lymphoma
Cancer is considered a complex genetic trait in which genetic susceptibility, environmental exposures and lifestyle factors all play a role. Our laboratory group investigates the genetic basis of cancer susceptibility at the population level. One of our primary interests is Lymphoma. We are using single nucleotide polymorphism (SNP) and haplotype-based case / control studies to discover novel genetic factors underlying susceptibility to Non-Hodgkin Lymphoma (NHL). These association studies will allow us to identify genetic factors underlying cancer susceptibility in the presence of genetic heterogeneity (when multiple genes contribute to a disease) and incomplete penetrance (when not all individuals who have the susceptibility factor are affected).