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  2. Our Research
  3. Barbara Lelj Garolla Di Bard

Barbara Lelj Garolla Di Bard

Professor
VCH Clinical Title(s)
Research Associate
Research Focus
Prostate Cancer
Degrees / Designations

Ph.D.

Contact Info
blelj@prostatecentre.com
604.874.4111 ext. 62418

Biography

I am interested in the role that molecular chaperones have in supporting treatment resistant prostate cancer.  In particular, I work on the intracellular small HspB1 (Hsp27) and on the only known extracellular chaperone, Clusterin. My research focuses on understanding the biophysical properties of these molecules in solution with the final aim of designing effective drug screenings. Moreover, I look for solution conditions optimal for crystal growth and for other techniques (NMR and EM) that can be used for three dimensional structure determinations.

The main technique I use to characterize protein self-association is analytical ultracentrifugation, which is very powerful in obtaining oligomerization profiles in a vast number of conditions. I also use protein purification, chaperone assays, various types of spectroscopy and site-directed mutagenesis to understand what role each protein domain or conserved residues have for protein activity.

I use the knowledge acquired from my studies to develop effective drug screening for these non-enzymatic proteins.

Publications

  • Protein science : a publication of the Protein Society -

    Roles of the N- and C-terminal sequences in Hsp27 self-association and chaperone activity.

    Lelj-Garolla B, Mauk AG
  • The Journal of biological chemistry -

    Self-association and chaperone activity of Hsp27 are thermally activated.

    Lelj-Garolla B, Mauk AG
  • Journal of molecular biology -

    Self-association of a small heat shock protein.

    Lelj-Garolla B, Mauk AG
  • The EMBO journal -

    Nanodiscs unravel the interaction between the SecYEG channel and its cytosolic partner SecA.

    Alami M, Dalal K, Lelj-Garolla B, Sligar SG, Duong F
  • Journal of molecular biology -

    Cofacial heme binding is linked to dimerization by a bacterial heme transport protein.

    Chan AC, Lelj-Garolla B, I Rosell F, Pedersen KA, Mauk AG, Murphy ME
Working in the lab

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