BSc. (Hons) Pharmacology
Ph.D Cell Biology
Dr. Cheryl Gregory-Evans was educated in the UK receiving her Ph.D in Cell Biology from the University of Strathcyde in Glasgow, under the direction of Dr Carolyn Converse. Her postdoctoral research began at the Jules Stein Eye Institute in Los Angeles (UCLA) and continued on her return to the Institute of Ophthalmology (UCL) in London. She received a prestigious Career Development Fellowship from the Wellcome Trust, leading to her appointment as Lecturer and then Senior Lecturer at Imperial College London. In September 2009 she was recruited to the Department of Ophthalmology at UBC.
My neurodevelopmental biology lab has two main interests in the filed of Ophthalmology
Tissue fusion defects: Tissue fusion is a recurring event in mammalian embryology, playing a fundamental role for instance in the development of the neural tube, palate and the optic fissure. Molecular players are being identified for each step during tissue fusion providing a framework for understanding the regulation of this process at the molecular level. Genetic studies have shown that gene defects causing failure of fusion in one location is often associated with failure of fusion in multiple tissues, thereby implying a subset of common mediators of fusion. We are studying optic fissure closure as a model system for epithelial fusion. Fusion defects lead to ocular coloboma which can damage the uveal tract, retina or optic nerve.
Aniridia: Aniridia is a pan-ocular condition characterized by an under-development of the iris tissue associated with cataract, Peters' anomaly, corneal disease and foveal hypoplasia. The majority of cases are caused by heterozygous genetic abnormalities affecting the PAX6 gene. We are interested in determining the precise signalling pathways that regulate normal iris development and why it goes wrong in aniridia. The critical questions to be addressed are: (i) what are the genes downstream of PAX6 that are crucial to iris development; (ii) what genes control normal foveal development.
- Human molecular genetics - 2012, Apr 25
- Canadian journal of ophthalmology. Journal canadien d'ophtalmologie - 2011, Aug 5
- Molecular vision - 2011, Jun 16
- Human molecular genetics - 2008, Nov 27
- Human molecular genetics - 2007, Oct 1