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  3. Cornelia Laule

Cornelia Laule

Associate Professor
VCH Clinical Title(s)
Associate Director, ICORD
Research Focus
Brain and NervesMultiple Sclerosis
Degrees / Designations

B.Sc., M.Sc., PhD

Contact Info
claule@physics.ubc.ca
604-675-8855
mripathology
corree-laule-2092602/

Biography

Dr. Cornelia Laule is a physicist who has been conducting magnetic resonance research for over two decades. She is jointly appointed as an associate professor in the Department of Radiology and the Department of Pathology and Laboratory Medicine, and is an associate director of the International Collaboration on Repair Discoveries (ICORD). 

Dr. Laule is interested in understanding the microstructural and pathological determinants which govern magnetic resonance signal changes in central nervous system (CNS) tissue. Her primary areas of research are multiple sclerosis and spinal cord injuries, and she has extensive experience imaging both in vivo and post mortem brain and spinal cord, ranging from basic physics technical development to clinical applications. She also has conducted research in many other CNS applications including schizophrenia, cervical spondylotic myelopathy, PKU, Krabbe Disease, Huntington’s Disease, depression, brain tumours, vascular cognitive impairment, development, aging, dyslexia, and dyscalculia, as well the characterization of normal controls. She is particularly interested in myelin and how variations in myelin composition and structure influence MRI measures.

News and Awards

VCHRI SPARKS 2024 recipients

Jun 3, 2024

Ask an expert: Who runs the (science) world?

Feb 5, 2019

Publications

  • Magnetic resonance in medicine -

    A data-driven T₂ relaxation analysis approach for myelin water imaging: Spectrum analysis for multiple exponentials via experimental condition oriented simulation (SAME-ECOS).

    Liu H, Joseph TS, Xiang QS, Tam R, Kozlowski P, Li DKB, MacKay AL, Kramer JLK, Laule C
  • Journal of neuroimaging : official journal of the American Society of Neuroimaging -

    Water content changes in new multiple sclerosis lesions have a minimal effect on the determination of myelin water fraction values.

    Vavasour IM, Chang KL, Combes AJE, Meyers SM, Kolind SH, Rauscher A, Li DKB, Traboulsee A, MacKay AL, Laule C
  • Multiple sclerosis (Houndmills, Basingstoke, England) -

    Characterization of multiple sclerosis neuroinflammation and neurodegeneration with relaxation and diffusion basis spectrum imaging.

    Vavasour IM, Sun P, Graf C, Yik JT, Kolind SH, Li DK, Tam R, Sayao AL, Schabas A, Devonshire V, Carruthers R, Traboulsee A, Moore GW, Song SK, Laule C
  • Journal of neuroimaging : official journal of the American Society of Neuroimaging -

    Nonlesional diffusely abnormal appearing white matter in clinically isolated syndrome: Prevalence, association with clinical and MRI features, and risk for conversion to multiple sclerosis.

    Holmes RD, Vavasour IM, Greenfield J, Zhao G, Lee JS, Moore GRW, Tam R, Metz LM, Trablousee A, Li DKB, Laule C
  • NeuroImage -

    Temperature dependence and histological correlation of inhomogeneous magnetization transfer and myelin water imaging in ex vivo brain.

    Prevost VH, Yung A, Morris SR, Vavasour IM, Samadi-Bahrami Z, Moore GRW, Laule C, Mackay A, Kozlowski P
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