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  1. Home
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  3. Yemin Wang

Yemin Wang

Assistant Professor
VCH Clinical Title(s)
Pathology
Research Focus
Cancers
Degrees / Designations
PhD
Contact Info
yewang@bccrc.ca
yemin-wang-7b315b29/

Biography

Dr. Yemin Wang is an assistant professor in the Department of Pathology and Laboratory Medicine at the University of British Columbia, as well as a senior research scientist in the Ovarian Cancer Research (OVCARE) Center and Vancouver Prostate Centre at Vancouver Coastal Health Research Institute. 

Dr. Wang’s lab studies how genetic mutations drives the development and progression of rare aggressive ovarian and endometrial cancers to inform targeted therapeutics. The overarching theme of his research is to dissect mechanisms by which genetic and epigenetic events drive malignant transformation and subsequent progression to a poorly differentiated and highly aggressive state that inform the development of prevention and targeted therapeutics. Two major types of cancers that his team studies include SWI/SNF-mutant cancers and DICER1 syndrome-associated cancers.

Dr. Wang obtained his PhD degree in Experimental Medicine at the University of British Columbia in 2009, studying the roles of ING family proteins in melanoma pathogenesis. He then pursued postdoctoral studies at the Fred Hutchison Cancer Research Centre in Seattle, exploring the role of microRNAs in DNA damaging response and chemoresistance. In 2012, he joined the laboratory of Dr. David Huntsman lab at BC Cancer Research Centre as postdoctoral fellows of Canadian Institutes of Health Research and Michael Smith Foundation for Health Research to study how genetic mutations in microRNA biogenesis gene DICER1 drive rare ovarian cancer development. 

News and Awards

Cancer driver discovery opens up treatment pathways for rare pediatric disease

Sep 25, 2023

Publications

  • Histopathology -

    Prognostic values of molecular subtypes and SWI/SNF protein expression in de-differentiated/undifferentiated endometrial carcinoma.

    Shin CY, Gokbayrak B, Tao VL, Almadani N, S Li E, Ho R, Kommoss FK, Huvila J, Chiu D, Leung S, Tessier-Cloutier B, Huntsman DG, Gilks CB, McAlpine JN, Hoang L, Wang Y
  • Cancer research -

    Biallelic Dicer1 Mutations in the Gynecologic Tract of Mice Drive Lineage-Specific Development of DICER1 Syndrome-Associated Cancer.

    Wang Y, Chen SY, Ta M, Senz J, Tao LV, Thornton S, Tamvada N, Yang W, Moscovitz Y, Li E, Guo J, Shen C, Douglas JM, Ei-Naggar AM, Kommoss FKF, Underhill TM, Singh N, Gilks CB, Morin GB, Huntsman DG
  • Nature communications -

    Alanine supplementation exploits glutamine dependency induced by SMARCA4/2-loss.

    Zhu X, Fu Z, Chen SY, Ong D, Aceto G, Ho R, Steinberger J, Monast A, Pilon V, Li E, Ta M, Ching K, Adams BN, Negri GL, Choiniere L, Fu L, Pavlakis K, Pirrotte P, Avizonis DZ, Trent J, Weissman BE, Klein Geltink RI, Morin GB, Park M, Huntsman DG, Foulkes WD, Wang Y, Huang S
  • Gynecologic oncology -

    Re-assigning the histologic identities of COV434 and TOV-112D ovarian cancer cell lines.

    Karnezis AN, Chen SY, Chow C, Yang W, Hendricks WPD, Ramos P, Briones N, Mes-Masson AM, Bosse T, Gilks CB, Trent JM, Weissman B, Huntsman DG, Wang Y
  • PloS one -

    Establishment and characterization of VOA1066 cells: An undifferentiated endometrial carcinoma cell line.

    Wang Y, Tao VL, Shin CY, Salamanca C, Chen SY, Chow C, Köbel M, Ben-Neriah S, Farnell D, Steidl C, Mcalpine JN, Gilks CB, Huntsman DG
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