Research Study

Biorest Liposomal Alendronate Administration for Diabetic Patients Undergoing Drug-Eluting Stent Percutaneous Coronary Intervention
Principal Investigator 
David Wood


Body Locations and Systems 
Diabetic Heart Disease
Disorders and Conditions 
Diabetes Complications 
Study Start/End 
Jun 27, 2017 to Dec 31, 2018
Vancouver General Hospital
Naomi Uchida
Email Address
Purpose of Study 

The main objective of this study is to assess the safety, efficacy and dose response of LABR-312 administered intravenously at the time of percutaneous coronary intervention (PCI) with a drug eluting stent in reducing restenosis as measured by Optical Coherence Tomography (OCT) at 9 months post procedure in patients with diabetes mellitus (DM).

Administration of LABR-312 at the time of PCI will reduce restenosis compared with placebo as assessed by the OCT endpoint of % neointimal hyperplasia (%NIH) volume at 9 months in patients with DM.


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