Research Study

Imaging Tau Accumulation with PBB3 in Healthy Controls
Principal Investigator 
A Jon Stoessl


Body Locations and Systems 
Parkinson's Disease
Diagnosis and Therapy 
MRI Scans
Study Start/End 
Dec 1, 2014 to Dec 31, 2019
UBC Hospital
Jess McKenzie, Imaging Coordinator
Email Address
Purpose of Study 

Parkinson's disease results from the loss of dopamine producing brain cells; however, the mechanism that start and continue this loss are still largerly unknkown. Recent research has suggested a protein called tau may contribute to the development and progression of Parksinon's disease. Using Positron Emission Tomography (PET), a brain imaging technique, we hope to determine if and how much tau is present in healthy control subjects. This control data will then be used for comparison for data collected in patients with Parkinson's and related diseases.


Inclusion Criteria:

  • We are looking for healthy men between the ages of 19 & 85 and healthy women between the ages of 30 and 85 who are interested in particpating in research using PET brain scanning. Potential candidates should not have Parkinson's disease, depression, or other memory or mood disorders, and no first degree relative with Parkinson's disease. Female candidates cannot particpate if they are pregnant or breastfeeding.
  • Particpants will be invited to complete 1 PET brain scan that lasts 70 minutes, and one 5-7 minute MRI scan to help with image analysis. Brief motor, mood and cognitive assessments will aslo be completed.

Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers and email addresses are provided for obtaining additional information on specific clinical research trials only. If you have specific questions which require clinical expertise, please call your primary care physician.