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  1. Home
  2. Participate in Research
  3. Investigating ocrelizumab for relapsing multiple sclerosis patients
Research Study

A Randomized, Open-Label, Parallel-Group, Non-Inferiority Study Comparing Efficacy, Safety, and Tolerability of an Experimental Drug After Switching from Ocrelizumab in Participants Living with Relapsing Multiple Sclerosis, Followed by Open-Label Treatment with the Experimental Drug (RESHAPE)

Principal Investigator
Alice Schabas

Overview

Body Locations and Systems
Brain and Nerves
Multiple Sclerosis
Immune System
ClinicalTrials.gov#
NCT06846281
Status
Recruiting
Start/End Dates
Jul 1, 2026 Aug 31, 2027
Locations
Djavad Mowafaghian Centre for Brain Health
Name/Title
Sara Tipnis, Clinical Research Coordinator
Phone
604-822-1758
Email Address
sarah.tipnis@ubc.ca
Purpose of Study

The purpose of this study is to find out if an experimental drug could be an alternative therapy for patients who are over 40 years old, have previously been on ocrelizumab (Ocrevus) for at least 18 months, and have relapsing multiple sclerosis (RMS).

The study is expected to be approximately 48 months with on-site visits every three months. Participants will be randomly selected to either receive the experimental drug or remain on ocrelizumab. The experimental drug is an oral pill while ocrelizumab is an IV infusion treatment. Other activities will include magnetic resonance imaging (MRI) scans, blood draws, physical and neurological exams, electrocardiograms (ECGs) and other testing designed to measure health and MS disease.

Eligibility

Visit ClinicalTrials.gov for more information.

Disclaimer

Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers and email addresses are provided for obtaining additional information on specific research studies only. If you have specific questions which require clinical expertise, please call your primary care physician.

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