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  1. Home
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  3. Matthew Farrer

Matthew Farrer

Professor
VCH Clinical Title(s)
Professor
Research Focus
Rehabilitation Intervention
Contact Info
www.can.ubc.ca
mfarrer@can.ubc.ca
604-822-0322

Biography

An ambitious researcher, Dr. Matthew Farrer has made several influential discoveries in neurogenetics, and is critically acclaimed for his work on the genetics of Parkinson’s disease. Before accepting his position as Canada Excellence Research Chair in Neurogenetics and Translational Neuroscience at UBC, Farrer was a professor of molecular neuroscience and Director of the Division of Neurogenetics, the Transgenic Core Facility, and several neurogenetics laboratories at Mayo Clinic, Jacksonville, Florida. In 2008, he was named a Mayo Clinic Distinguished Investigator, the Clinic’s highest award for research excellence, for his outstanding contributions to neurogenetics and translational neuroscience. At the Clinic, he worked on innovating new treatments for patients suffering from neurologic disease by refining diagnosis and identifying biomarkers of early and progressive disease. Farrer’s studies on model development and characterization have helped define the biologic systems perturbed by genetic mutations, and have laid the foundation for new and effective therapies. As a scientist, Farrer is currently cited as having made the greatest impact on the field of Parkinson’s disease research in the past decade. Farrer holds a PhD in human genetics from Imperial College London, United Kingdom, and a bachelor’s degree in biochemistry from King’s College London, UK. His thesis studies focused on brain disorders, namely age-associated cognitive dysfunction in Down syndrome, and the complex trait genetics of trisomy 21. He was also a postdoctoral fellow in medical and community genetics at the Kennedy-Galton Centre of Medical and Community Genetics, St. Mark’s Hospital, Harrow, UK. His current research interests are age-related neurodegenerative disorders, with a focus on the molecular genetics and functional modeling of movement disorders, including Parkinson’s disease and Lewy body dementia.

News and Awards

People in profile: Stefano Cataldi

Nov 14, 2018

Top Graduating Doctoral Student Award and Rising Star Award 2018 Recipients

May 24, 2018

Publications

  • American journal of human genetics -

    Translation initiator EIF4G1 mutations in familial Parkinson disease.

    Chartier-Harlin MC, Dachsel JC, Vilariño-Güell C, Lincoln SJ, Leprêtre F, Hulihan MM, Kachergus J, Milnerwood AJ, Tapia L, Song MS, Le Rhun E, Mutez E, Larvor L, Duflot A, Vanbesien-Mailliot C, Kreisler A, Ross OA, Nishioka K, Soto-Ortolaza AI, Cobb SA, Melrose HL, Behrouz B, Keeling BH, Bacon JA, Hentati E, Williams L, Yanagiya A, Sonenberg N, Lockhart PJ, Zubair AC, Uitti RJ, Aasly JO, Krygowska-Wajs A, Opala G, Wszolek ZK, Frigerio R, Maraganore DM, Gosal D, Lynch T, Hutchinson M, Bentivoglio AR, Valente EM, Nichols WC, Pankratz N, Foroud T, Gibson RA, Hentati F, Dickson DW, Destée A, Farrer MJ
  • American journal of human genetics -

    VPS35 mutations in Parkinson disease.

    Vilariño-Güell C, Wider C, Ross OA, Dachsel JC, Kachergus JM, Lincoln SJ, Soto-Ortolaza AI, Cobb SA, Wilhoite GJ, Bacon JA, Behrouz B, Melrose HL, Hentati E, Puschmann A, Evans DM, Conibear E, Wasserman WW, Aasly JO, Burkhard PR, Djaldetti R, Ghika J, Hentati F, Krygowska-Wajs A, Lynch T, Melamed E, Rajput A, Rajput AH, Solida A, Wu RM, Uitti RJ, Wszolek ZK, Vingerhoets F, Farrer MJ
  • The Lancet. Neurology -

    Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.

    Ross OA, Soto-Ortolaza AI, Heckman MG, Aasly JO, Abahuni N, Annesi G, Bacon JA, Bardien S, Bozi M, Brice A, Brighina L, Van Broeckhoven C, Carr J, Chartier-Harlin MC, Dardiotis E, Dickson DW, Diehl NN, Elbaz A, Ferrarese C, Ferraris A, Fiske B, Gibson JM, Gibson R, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Jasinska-Myga B, Jeon BS, Kim YJ, Klein C, Kruger R, Kyratzi E, Lesage S, Lin CH, Lynch T, Maraganore DM, Mellick GD, Mutez E, Nilsson C, Opala G, Park SS, Puschmann A, Quattrone A, Sharma M, Silburn PA, Sohn YH, Stefanis L, Tadic V, Theuns J, Tomiyama H, Uitti RJ, Valente EM, van de Loo S, Vassilatis DK, Vilariño-Güell C, White LR, Wirdefeldt K, Wszolek ZK, Wu RM, Farrer MJ,
  • Nature genetics -

    Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.

    Höglinger GU, Melhem NM, Dickson DW, Sleiman PM, Wang LS, Klei L, Rademakers R, de Silva R, Litvan I, Riley DE, van Swieten JC, Heutink P, Wszolek ZK, Uitti RJ, Vandrovcova J, Hurtig HI, Gross RG, Maetzler W, Goldwurm S, Tolosa E, Borroni B, Pastor P, , Cantwell LB, Han MR, Dillman A, van der Brug MP, Gibbs JR, Cookson MR, Hernandez DG, Singleton AB, Farrer MJ, Yu CE, Golbe LI, Revesz T, Hardy J, Lees AJ, Devlin B, Hakonarson H, Müller U, Schellenberg GD
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