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  3. Orson Moritz

Orson Moritz

Professor
Academic Appointment
Professor
Research Focus
Eyes and Vision
Contact Info
olmoritz@mail.ubc.ca
604-875-4357

Biography

Dr. Orson Moritz is a professor in the Department of Ophthalmology and Visual Sciences at the University of British Columbia. He studies rod and cone photoreceptors, the light-sensitive cells of the retina responsible for vision. He uses gene-manipulation techniques and animal models to examine how these cells work, and why they die in inherited retinal degenerative disorders such as retinitis pigmentosa, cone-rod dystrophy and macular degeneration, to develop drug and gene therapy-based treatments. He also investigates how environmental conditions, such as light exposure and vitamin A, influence these disorders.

Publications

  • Experimental eye research -

    Identification and cellular localization in Xenopus laevis photoreceptors of three Peripherin-2 family members, Prph2, Rom1 and Gp2l, which arose from gene duplication events in the common ancestors of jawed vertebrates.

    Tam BM, Taylor JS, Moritz OL
  • Journal of cell science -

    Distinct roles for prominin-1 and photoreceptor cadherin in outer segment disc morphogenesis in CRISPR-altered .

    Carr BJ, Stanar P, Moritz OL
  • Autophagy -

    Autophagy in rod photoreceptors is independently regulated by phototransduction and misfolded RHO{{sup}}P23H{{/sup}}.

    Wen RH, Stanar P, Tam B, Moritz OL
  • The Journal of neuroscience : the official journal of the Society for Neuroscience -

    Opposing Effects of Valproic Acid Treatment Mediated by Histone Deacetylase Inhibitor Activity in Four Transgenic Models of Retinitis Pigmentosa.

    Vent-Schmidt RYJ, Wen RH, Zong Z, Chiu CN, Tam BM, May CG, Moritz OL
  • The Journal of neuroscience : the official journal of the Society for Neuroscience -

    Photoactivation-induced instability of rhodopsin mutants T4K and T17M in rod outer segments underlies retinal degeneration in X. laevis transgenic models of retinitis pigmentosa.

    Tam BM, Noorwez SM, Kaushal S, Kono M, Moritz OL
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