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  3. Ryan Hoiland

Ryan Hoiland

Assistant Professor
Academic Appointment
Assistant Professor
Research Focus
Brain and NervesSpinal Cord Injury
Contact Info
ryan.hoiland@ubc.ca
RyanLeoHoiland

Biography

Dr. Ryan Hoiland is a member of the Djavad Mowafaghian Centre for Brain Health and the International Collaboration On Repair Discoveries (ICORD), an investigator with the Centre for Chronic Disease Prevention and Management and an assistant professor in the Department of Cellular and Physiological Sciences at the University of British Columbia (UBC). He completed his PhD at UBC Okanagan, where he studied cerebrovascular physiology and human adaptation to hypoxia. As a postdoctoral fellow, Dr. Hoiland investigated the pathophysiology of hypoxic-ischemic brain injury as well as traumatic spinal cord injury, with a focus on mitigating secondary hypoxic injury. Collectively, his training involved studying how the central nervous system responds to hypoxia in pre-clinical disease models, healthy humans and patients.

His laboratory aims to determine neuroprotective strategies to improve outcomes for patients suffering an acute central nervous system injury. He conducts studies across the translational continuum in pre-clinical disease models, healthy human studies and clinical patient studies to characterize the pathophysiology of acute traumatic and/or ischemic central nervous system injury. This includes a focus on determining how to optimize oxygen delivery to the brain and spinal cord following an acute injury, with a further interest in cerebrovascular regulation as it pertains to health, disease and adaptions to stressors such as exercise and the environment.

News and Awards

People in profile: Ryan Hoiland

Nov 16, 2021

Publications

  • Intensive care medicine -

    Clinical targeting of the cerebral oxygen cascade to improve brain oxygenation in patients with hypoxic-ischaemic brain injury after cardiac arrest.

    Hoiland RL, Robba C, Menon DK, Citerio G, Sandroni C, Sekhon MS
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism -

    Hemoglobin and cerebral hypoxic vasodilation in humans: Evidence for nitric oxide-dependent and -nitrosothiol mediated signal transduction.

    Hoiland RL, MacLeod DB, Stacey BS, Caldwell HG, Howe CA, Nowak-Flück D, Carr JM, Tymko MM, Coombs GB, Patrician A, Tremblay JC, Van Mierlo M, Gasho C, Stembridge M, Sekhon MS, Bailey DM, Ainslie PN
  • JAMA neurology -

    Neurologic Prognostication After Cardiac Arrest Using Brain Biomarkers: A Systematic Review and Meta-analysis.

    Hoiland RL, Rikhraj KJK, Thiara S, Fordyce C, Kramer AH, Skrifvars MB, Wellington CL, Griesdale DE, Fergusson NA, Sekhon MS
  • The Journal of physiology -

    Nitric oxide contributes to cerebrovascular shear-mediated dilatation but not steady-state cerebrovascular reactivity to carbon dioxide.

    Hoiland RL, Caldwell HG, Carr JMJR, Howe CA, Stacey BS, Dawkins T, Wakeham DJ, Tremblay JC, Tymko MM, Patrician A, Smith KJ, Sekhon MS, MacLeod DB, Green DJ, Bailey DM, Ainslie PN
  • Circulation research -

    Brain Hypoxia Is Associated With Neuroglial Injury in Humans Post-Cardiac Arrest.

    Hoiland RL, Ainslie PN, Wellington CL, Cooper J, Stukas S, Thiara S, Foster D, Fergusson NA, Conway EM, Menon DK, Gooderham P, Hirsch-Reinshagen V, Griesdale DE, Sekhon MS
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