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  3. Clostridium Difficile Infections

Clostridium Difficile Infections

Closed for Recruitment

Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile - Associated Diarrhea

This clinical study is conducted to assess the efficacy of cadazolid compared to vancomycin in subjects with Clostridium difficile-associated diarrhea (CDAD).

Status
Closed for Recruitment
Principal Investigator
Theodore Steiner
Body Locations and Systems
Clostridium Difficile Infections
Area
Vancouver
Age
18 and above

A Prospective Trial of Frozen-and-Thawed Fecal Microbiota Transplantation for Recurrent Clostridium Difficile Infection

The primary goal of this proposal is to study the outcome of patients with recurrent Clostridium Difficile Infection (CDI) treated with frozen Fecal Microbiota Transplantation (FMT) in an open-labelled controlled trial.

Status
Closed for Recruitment
Principal Investigator
Theodore Steiner
Body Locations and Systems
Clostridium Difficile Infections
Area
Vancouver
Age
18 and above

Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection (PUNCHCD2)

This is the first prospective, multi-center, double-blinded, randomized controlled study of a microbiota suspension derived from intestinal microbes. Patients who have had at least two recurrences of C. difficile infection (CDI) after a primary episode and have completed at least two rounds of standard-of-care oral antibiotic therapy or have had at least two episodes of severe CDI resulting in hospitalization may be eligible for the study.

Status
Closed for Recruitment
Principal Investigator
Theodore Steiner
Body Locations and Systems
Clostridium Difficile Infections
Area
Vancouver
Age
18 and above

Study of a Candidate Clostridium Difficile Toxoid Vaccine (Cdiffense) in Subjects at Risk for C. Difficile Infection

The aim of this study is to evaluate the efficacy of the candidate Clostridium difficile (C. difficile) vaccine to prevent primary symptomatic C. difficile infection (CDI) in subjects a risk for CDI where there is a substantial unmet medical need.

Status
Closed for Recruitment
Principal Investigator
Theodore Steiner
Body Locations and Systems
Clostridium Difficile Infections
Area
Vancouver
Age
50 and above

Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT): A Feasibility Clinical Trial (PROSPECT)

Probiotics are commercially available live bacteria thought to have health benefits when ingested. A literature review of probiotic studies in the intensive care unit (ICU) found that in patients who receive probiotics, there is a 25% reduction in lung infection, known as ventilator-associated pneumonia (VAP). There is also an 18% reduction in the chance of developing any infection in the ICU. However, the studies reviewed were small and not well done. Therefore, whether probiotics are really helpful or not is unclear.

Status
Closed for Recruitment
Principal Investigator
Peter Dodek
Body Locations and Systems
Pneumonia
Clostridium Difficile Infections
Area
Vancouver
Age
18 and above
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