Research Study

Effect of Immunosuppressive Medication Use on Patient Outcomes Following Kidney Transplantation Failure
Principal Investigator 
John Gill

Overview

Body Locations and Systems 
ClinicalTrials.gov# 
nct01296061
Status 
Closed to Recruitment
Study Start/End 
Mar 2, 2011 to May 24, 2018
Locations 
St. Paul's Hospital, Vancouver General Hospital
Name/Title 
Joanne Lau, Study Coordinator
Phone 
604-682-2344 ext. 64708
Purpose of Study 

Primary Hypotheses:

  • Among patients who retain the failed kidney transplant, those who continue immunosuppressant medication will have more deaths than patients who discontinue these drugs
  • Among patients who retain the failed kidney transplant, those who continue immunosuppressant medication will have more hospitalizations for sepsis than patients who discontinue these drugs
  • Among patients who retain the failed kidney transplant, those who continue immunosuppressant medication will have fewer rejection events than patients who discontinue these drugs

Secondary Hypotheses:

  • Patients who undergo elective nephrectomy (to remove the failed kidney transplant) will have fewer deaths than those who retain the failed kidney transplant
  • Patients who undergo elective nephrectomy (to remove the failed kidney transplant) will have fewer hospitalizations for sepsis than those who retain the failed kidney transplant
  • Among patients who retain the failed kidney transplant, those who continue immunosuppressant medication will have lower levels of allosensitization (anti-HLA antibodies) than those who discontinue these drugs
  • Patients who undergo elective nephrectomy will have higher levels of allosensitization (anti-HLA antibodies) than patients who retain the failed kidney transplant
Eligibility 

Visit ClinicalTrials.gov for more information.

Disclaimer 

Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers and email addresses are provided for obtaining additional information on specific clinical research trials only. If you have specific questions which require clinical expertise, please call your primary care physician.