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  3. Transplantation and Donation

Transplantation and Donation

Recruiting

Addressing issues and therapeutics in transplantation for COVID-19

The purpose of this study is to assess COVID-19 prophylactic/therapeutic safety and effectiveness in transplant patients, assess mental health impacts of COVID-19 on transplant patients and families, develop strategies to improve well-being, and determine the economic burden and value of emerging and existing prophylactic/therapeutic options for COVID-19 in transplant patients.

Status
Recruiting
Principal Investigator
Sara Belga
Age
19 and above

Investigating islet cell infusion in people with type 1 diabetes and kidney transplant

The purpose of this study is to test whether an investigational infusion of islet cells (called VX-880) would be safe, tolerable and effective in providing better control of blood sugar levels for patients with type 1 diabetes who have a kidney transplant.

Status
Recruiting
Principal Investigator
Breay Paty
Body Locations and Systems
Endocrine System
Age
18-65

Investigating treatment for patients with chronic graft-versus-host disease

The purpose of this study is to evaluate the safety, tolerability and preliminary activity of axatilimab in combination with ruxolitinib and to assess the contribution of axatilimab to the combination treatment effect in participants with chronic graft-versus-host disease.

Status
Recruiting
Principal Investigator
Jennifer White
Body Locations and Systems
Blood, Heart and Circulation
Immune System
Age
12 and above

Understanding the experiences of relocated transplant patients

The purpose of this study is to understand and document the experiences of patients who live at least 60 minutes outside of the Lower Mainland and who are traveling to Vancouver for a solid organ transplant. The research team aims to document the psychological, social, emotional and cultural impact for patients leaving their communities to access care in Vancouver. The study will also capture the associated out-of-pocket costs that these transplant patients incur before, during and after the transplant operation.

Status
Recruiting
Principal Investigator
Jude Kornelsen
Body Locations and Systems
Blood, Heart and Circulation
Digestive System
Kidneys and Urinary System
Lungs and Breathing

Testing the effectiveness of belumosudil for bilateral lung transplant patients

The purpose of this study is to help the study sponsor determine whether adding the study drug, belumosudil, to usual treatment (immunosuppression per transplant site and azithromycin) is better, the same or worse than the usual treatment approach alone for chronic lung rejection. 

Status
Recruiting
Principal Investigator
Céline Bergeron
Body Locations and Systems
Lungs and Breathing
Age
18 and above

Preventing skin cancer with nicotinamide in transplant patients

The purpose of this study is to determine whether an oral vitamin called nicotinamide can help prevent skin cancer in 396 high-risk kidney, liver, heart and lung transplant recipients. Participants will be involved in the study for four years and will visit the study doctor or clinical research staff every 17 weeks. Participants will receive nicotinamide or a placebo, taken orally for the entire follow-up period, which will last up to 208 weeks.

Status
Recruiting
Principal Investigator
Sunil Kalia
Body Locations and Systems
Kidneys and Urinary System
Skin, Hair and Nails
Age
18 and above

Evaluating the efficacy of islet cell therapy for type 1 diabetes

The purpose of this study is to test whether an investigational infusion of islet cells (called VX-880) would be safe, tolerable and effective in providing better control of blood sugar levels for type 1 diabetes by improving insulin independence and islet cell function. This will be tested in patients with episodes of severe hypoglycemia and difficulty recognizing low blood sugar. 

Status
Recruiting
Principal Investigator
Breay Paty
Body Locations and Systems
Endocrine System
Age
18-65

Assessing the efficacy of a drug in preventing kidney transplant rejection

The purpose of this study is to assess the overall efficacy, safety and tolerability of BIVV020 for prevention and treatment of antibody-mediated rejection in adult kidney transplant recipients.

Status
Recruiting
Principal Investigator
John Gill
Body Locations and Systems
Kidneys and Urinary System
Age
18 and above

Testing the safety of an RSV vaccine in lung or kidney transplant recipients

The purpose of this study is to evaluate the immune response and safety of a new vaccine in preventing diseases due to infection with respiratory syncytial virus (RSV). This RSV vaccine will be tested in older adults who are recipients of lung or kidney transplants and are at an increased risk of RSV compared to healthy older adults. 

Status
Recruiting
Principal Investigator
Céline Bergeron
Body Locations and Systems
Immune System
Lungs and Breathing
Age
50 and above

Evaluating itolizumab to treat chronic graft-versus-host disease

The purpose of the study is to investigate the safety and efficacy of itolizumab versus placebo in individuals with acute graft-versus-host disease, when combined with corticosteroids as a first line treatment.

Status
Recruiting
Principal Investigator
Jennifer White
Body Locations and Systems
Immune System
Age
12 and above

QPI-1002 for Prevention of Delayed Graft Function in Recipients of an Older Donor Kidney Transplant (ReGIFT)

The purpose of this trial is to evaluate the reduction in incidence and severity of delayed graft function with kidney allografts from donors >45 years after brain death (DBD).

Status
Recruiting
Principal Investigator
Jagbir Gill
Body Locations and Systems
Kidney Transplantation
Area
Vancouver
Age
18 and above

Evaluating coronary artery disease screening for kidney transplant candidates

The purpose of this study is to determine if coronary artery disease (CAD) screening is necessary for patients on the waiting list for kidney transplantation. Patients on the waiting list for kidney transplantation are at risk for CAD. Currently, patients without any symptoms of CAD undergo annual testing to determine if they have disease. The optimal strategy to monitor and maintain the cardiac fitness of these patients is unknown.

Status
Recruiting
Principal Investigator
Jagbir Gill
Body Locations and Systems
Blood, Heart and Circulation
Coronary Artery Disease
Kidneys and Urinary System
Area
Vancouver
Age
18 and above

A Pilot Study Comparing the Use of Low-target Versus Conventional Target Advagraf (Astellas)

While the incidence of acute rejection and early graft loss have improved dramatically with the advent of newer immunosuppressant medications, improvements in long-term patient and allograft survival after kidney transplantation have not been achieved. The specific drug combination that provides the best outcomes with the least amount of side effects is not known. Each kidney transplant center uses the combination of drugs that they believe is optimal.

Status
Recruiting
Principal Investigator
Jagbir Gill
Body Locations and Systems
Kidney Transplantation
Area
Vancouver
Age
19 and above

Closed for Recruitment

Evaluating axatilimab to treat chronic graft-versus-host disease

The purpose of this study is to evaluate the efficacy, safety and tolerability of axatilimab at three different dose levels in participants with recurrent or refractory active chronic graft versus host disease (cGVHD) who have received at least two prior lines of systemic therapy.

Status
Closed for Recruitment
Principal Investigator
Jennifer White
Body Locations and Systems
Immune System
Age
2 and above

Kidney Transplant Failure

Primary Hypotheses:

Status
Closed for Recruitment
Body Locations and Systems
Kidney Transplantation
Dialysis
Kidney Failure
Area
Vancouver
Age
18 and above
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