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  3. Schizophrenia

Schizophrenia

Recruiting

Comparing non-invasive neurostimulation therapies for schizophrenia

The purpose of this study is to compare two non-invasive neurostimulation techniques (ECT and MST) in the treatment of schizophrenia and schizoaffective disorder.

Status
Recruiting
Principal Investigator
Fidel Vila-Rodriguez
Body Locations and Systems
Brain and Nerves
Age
19 and above

Improving our understanding of functioning in psychosis

The purpose of this study is to contribute to improving our understanding of functioning in psychosis. Memory is an important predictor of how well individuals affected by schizophrenia and related psychoses are able function in their social and occupational lives. However, the exact structures and functions in the brain responsible for this relationship are currently unknown.

Status
Recruiting
Principal Investigator
Todd Woodward
Body Locations and Systems
Brain and Nerves
Age
18-60

Understanding the link between schizophrenia, schizoaffective disorder and heat

The purpose of this study is to understand the link between schizophrenia and heat. People with schizophrenia have died at disproportionately high rates in recent heat events. While there is some physiological and biomedical understanding of thermoregulation in people with schizophrenia, understandings of their social vulnerability is lacking. Through interviews with people with schizophrenia, as well as their caregivers and loved ones, the study team aims to get a fuller understanding of their experiences in extreme heat events.

Status
Recruiting
Principal Investigator
Liv Yoon

Brain Health and Exercise in Schizophrenia (PEHP)

To determine the effects of aerobic exercise on hippocampal volumes and severity of psychotic symptoms in a population of psychosis patients compared to healthy age/gender matched volunteers. Psychosis patients often suffer from a number of cognitive difficulties, including poor memory function, poor problem-solving capacity and difficulties with attention and concentration. These problems are not well addressed by current clinical treatments.

Status
Recruiting
Principal Investigator
Donna Jane M Lang
Body Locations and Systems
Brain
Area
Vancouver
Age
16-45

Contrasting Group Therapy Methods for Psychosis (MCT)

Current Canadian Clinical Practice guidelines emphasize the need for effective psychosocial adjuncts to pharmacotherapy for schizophrenia (Canadian Psychiatric Association 2005). This randomized control trial seeks to contribute to the body of evidence supporting psychosocial treatments by assessing the effectiveness of metacognitive training (MCT) and cognitive remediation (CR) at treating the persistent positive and cognitive symptoms of schizophrenia.

Status
Recruiting
Principal Investigator
Todd Woodward
Body Locations and Systems
Brain
Area
Vancouver
Age
19-60

The Music Study in Refractory Psychosis (MARS)

The perception of music requires coordinated neural activities in distributed multi-functional centers across both hemispheres. The association between musical abilities and other general cognitive functions have been studied in several populations with inconsistent results.

Status
Recruiting
Body Locations and Systems
Brain
Area
Vancouver
Age
18 and above

Study of the Effect of Dosing on Clozapine Levels (PK-CLZ)

The objectives of this 15-day study are:

  • To compare steady-state trough plasma concentrations of clozapine and its metabolite norclozapine when given once daily and twice daily (at the same total daily dose)
  • To determine if frequency of clozapine administration has an effect on:
    • Symptoms of schizophrenia
    • Adverse effects of clozapine
    • Fasting blood glucose, lipids, creatinine, and urea
    • Weight and waist circumference
Status
Recruiting
Principal Investigator
Ric Procyshyn
Body Locations and Systems
Brain
Area
Vancouver
Age
19-65
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