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  3. Schizophrenia

Schizophrenia

Recruiting

Brain Health and Exercise in Schizophrenia (PEHP)

To determine the effects of aerobic exercise on hippocampal volumes and severity of psychotic symptoms in a population of psychosis patients compared to healthy age/gender matched volunteers. Psychosis patients often suffer from a number of cognitive difficulties, including poor memory function, poor problem-solving capacity and difficulties with attention and concentration. These problems are not well addressed by current clinical treatments.

Status
Recruiting
Principal Investigator
Donna Jane M Lang
Body Locations and Systems
Brain
Area
Vancouver
Age
16-45

Contrasting Group Therapy Methods for Psychosis (MCT)

Current Canadian Clinical Practice guidelines emphasize the need for effective psychosocial adjuncts to pharmacotherapy for schizophrenia (Canadian Psychiatric Association 2005). This randomized control trial seeks to contribute to the body of evidence supporting psychosocial treatments by assessing the effectiveness of metacognitive training (MCT) and cognitive remediation (CR) at treating the persistent positive and cognitive symptoms of schizophrenia.

Status
Recruiting
Principal Investigator
Todd Woodward
Body Locations and Systems
Brain
Area
Vancouver
Age
19-60

The Music Study in Refractory Psychosis (MARS)

The perception of music requires coordinated neural activities in distributed multi-functional centers across both hemispheres. The association between musical abilities and other general cognitive functions have been studied in several populations with inconsistent results.

Status
Recruiting
Body Locations and Systems
Brain
Area
Vancouver
Age
18 and above

Study of the Effect of Dosing on Clozapine Levels (PK-CLZ)

The objectives of this 15-day study are:

  • To compare steady-state trough plasma concentrations of clozapine and its metabolite norclozapine when given once daily and twice daily (at the same total daily dose)
  • To determine if frequency of clozapine administration has an effect on:
    • Symptoms of schizophrenia
    • Adverse effects of clozapine
    • Fasting blood glucose, lipids, creatinine, and urea
    • Weight and waist circumference
Status
Recruiting
Principal Investigator
Ric Procyshyn
Body Locations and Systems
Brain
Area
Vancouver
Age
19-65
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